Title

Oxidative stress markers and atherogenic lipid alterations among chronic smokers

Authors

Gaurang Hasmukhbhai Suhagiya¹, Soham V Shah², Krupa Rajeshbhai Gondaliya³, Aditi Singh⁴*, Gazal Mangukiya⁵ & Huma Saiyad⁶

Affiliation

¹Department of Pediatrics, Shantabaa Medical College and General Hospital, Amreli, Gujarat, India; ²Department of Surgery, Dr N D Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India; ³Department of Casualty, Government Medical College, Surat, Gujarat, India; ⁴Department of Critical Care, Dr. Baba Saheb Ambedkar Hospital, New Delhi, India; ⁵Department of Emergency Medicine, B J Medical College, Ahmedabad, Gujarat, India; ⁶Department of Medicine, B J Medical College, Ahmedabad, Gujarat, India; *Corresponding author

Email

Gaurang Hasmukhbhai Suhagiya - E-mail: gaurangsuhagiya1996@gmail.com
Soham V Shah - E-mail: shahsoham0592@gmail.com
Krupa Rajeshbhai Gondaliya - E-mail: krupagondaliya9@gmail.com
Aditi Singh - E-mail: aditisingh814@gmail.com
Gazal Mangukiya - E-mail: gazalmangukiya26@gmail.com
Huma Saiyad - E-mail: saiyedhuma1@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

The constant entry of exogenous reactive oxygen species makes cigarette smoking one of the key contributors to systemic oxidative stress. Therefore, it is interest to compare the oxidative stress markers and lipid profiles of chronic smokers and age matched non-smokers. A cross-sectional examination of 200 males showed that serum Malondialdehyde (MDA) level was much higher and the SOD and CAT activities were much lower among smokers. Dyslipidemia and higher Atherogenic Index of Plasma were strongly positively related to oxidative stress. Thus, those oxidative biomarkers are potential cardiovascular risk predictors in chronic smokers.

Keywords

Oxidative stress, cigarette smoking, malondialdehyde, antioxidants, cardiovascular risk, atherogenic index.

Citation

Suhagiya et al. Bioinformation 21(12): 4917-4921 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.