Title
MSH6 and PMS2 expression in colorectal carcinoma
Authors
M Safin*, S. Marylilly & M.S. Janhavi
Affiliation
Department of Pathology,Sree Balaji Medical College and Hospital, Chennai-44, Tamilnadu, India; *Corresponding author
M Safin - E-mail: safurabi1997@gmail.com
S. Marylilly - E-mail: marylillypath@gmail.com
M.S. Janhavi - E-mail: dr.janhavi.m.s@gmail.com
Article Type
Research Article
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Microsatellite instability (MSI) is a key feature in colorectal carcinomas (CRCs), but its role in diagnosis and prognosis, particularly through immunohistochemical markers like MSH6 and PMS2, remains underexplored. Conducted at Sree Balaji Medical College and Hospital, 50 histologically confirmed CRC samples were analyzed. Combined loss of MSH6 and PMS2 (MSI-H) was found in 30% of cases, particularly in poorly differentiated tumors, T3 stage tumors, stage II and III cancers, and node-positive groups. Thus, understanding of microsatellite instability (MSI) detection in colorectal carcinomas (CRCs) using immune histochemical markers MSH6 and PMS2, improving diagnostic and prognostic approaches for CRC.
Keywords
Microsatellite instability, MSH6, PMS2, colorectal carcinoma, immunohistochemistry
Citation
Safin et al. Bioinformation 21(12): 4968-4973 (2025)
Edited by
Ritik Kashwani
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
