Title
Identification of Hub genes in melasma using integrated transcriptomic analysis
Authors
Akhtar Veg1, Mohd Murshad Ahmed2, Rafat Ali3 & Romana Ishrat1,*
Affiliation
1Centre for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia, New Delhi-110025, India; 2Albert Einstein College of Medicine, Yeshiva University, New York City; 3Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India; *Corresponding author
Romana Ishrat - E-mail: rishrat@jmi.ac.in
Akhtar Veg - E-mail: akhtar2206374@st.jmi.ac.in
Mohd Murshad Ahmed - E-mail: mohdmurshad.ahmed@einsteinmed.edu
Rafat Ali - E-mail: rs.rafat@jmi.ac.in
Article Type
Research Article
Date
Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026
Abstract
Melasma is a prevalent pigmentary disorder or hyper melanosis skin condition. It is characterized by evenly distributed hyperpigmented regions on the light exposed areas of the facial regions. Its management continues to be a therapeutic challenge due to the limited understanding of their pathogenesis. Therefore, it is of interest to report the molecular mechanism of melasma pathogenesis. By using the identification of key genes and pathways via integrate microarray datasets. These transcriptomics studies showed the complex multifactorial molecular mechanisms are involved in melasma production. These key pathways that are involve in oxidative stress, inflammatory signaling and dermal remodeling. This could give insights into a potential therapeutic target such as DNA repair regulators and metabolic stabilizers.
Keywords
Melasma, Hub genes, DEGs, transcriptomic analysis, gene expression profiling
Citation
Veg et al. Bioinformation 22(1): 1-8 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
