Title
Haemoglobin D-Punjab haemoglobinopathy, the silent epidemic: A prospective hospital based study in Gujarat, India
Authors
Garima Anandani1, Parth Goswami1*, Vaishali Bhankhodia1, Sagar Dholariya2, Yash Thesiya1 & Avani Dangar1
Affiliation
1Department of Pathology, AIIMS, Rajkot, Gujarat, India; 2Department of Biochemistry, AIIMS, Rajkot, Gujarat, India; *Corresponding author
Garima Anandani - E-mail: garima_anandani@yahoo.in
Parth Goswami - E-mail: goswamiparth42@gmail.com
Vaishali Bhankhodia - E-mail: vaishalibhankhodia@gmail.com
Sagar Dholariya - E-mail: drsagar.dholariya@gmail.com
Yash Thesiya - E-mail: yashthesiya@gmail.com
Avani Dangar - E-mail: avanidangaro68@gmail.com
Article Type
Research Article
Date
Received January 1, 2026; Revised January
31, 2026; Accepted January 31, 2026, Published January 31, 2026
Abstract
Haemoglobin D-Punjab (HbD-Punjab) is a globally prevalent variant that remains under-recognized in the Saurashtra-Kutch region of Gujarat. Therefore, it is of interest to determine its prevalence using High-Performance Liquid Chromatography (HPLC) and to evaluate associated clinical and haematological features. A cross-sectional analysis of 22 confirmed HbD cases revealed predominantly heterozygous HbD-Punjab, with a marked female predominance and mixed symptomatic presentation. HbD percentages showed no meaningful correlation with haemoglobin concentration, red cell indices, or iron parameters. Thus, we show the need for broader population-based screening to improve early detection and management of HbD haemoglobinopathy in Gujarat.
Keywords
Gujarat, Haemoglobinopathy, HbD-Punjab, High-performance liquid chromatography
Citation
Anandani et al. Bioinformation 22(1): 15-20 (2026)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
