Title

A review on levothyroxine treatment on bone age in children with long standing untreated acquired hypothyroidism

Authors

Abhay Jain^1,*, Shailesh Sudani² & Zalak Upadhyay²

Affiliation

¹Department of Pediatrics, American International Institute of Medical Sciences, Udaipur, Rajasthan, India; ²Department of Pediatrics, Shantabaa Medical College and General Hospital, Amreli, Gujarat, India; *Corresponding author

Email

Abhay Jain - E-mail: abhaytanu77@gmail.com
Shailesh Sudani - E-mail: drshaileshsudani263@gmail.com
Zalak Upadhyay - E-mail: drzmupadhyay@yahoo.co.in

Article Type

Review

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Children with long-standing untreated hypothyroidism often experience delayed bone maturation and impaired linear growth, which can persist even after the initiation of therapy. Therefore, it is of interest to review the effects of levothyroxine therapy on bone age (BA) advancement and growth outcomes in children with hypothyroidism. Known data shows that levothyroxine therapy accelerates bone age progression and improves growth velocity and height outcomes. Early and adequate treatment yields the greatest benefits; however, delayed or prolonged untreated disease limits full height recovery. Thus, timely levothyroxine replacement is essential to minimize growth impairment and preserve adult height potential in pediatric hypothyroidism.

Keywords

Hypothyroidism, thyroxine, levothyroxine, bone age, growth velocity, height SDS, pediatric

Citation

Jain et al. Bioinformation 22(1): 31-37 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.