Title

Exploring molecular pathways in Alzheimer's disease neurodegeneration using biomarkers

Authors

Ankan Mondal¹*, Sangeeta Gupta², Aditya Bhattacharjee³, Amrit Podder⁴ & Parth Jani⁵

Affiliation

¹Department of Neurosurgery, R. G. Kar Medical College, Kolkata, India; ²Department of Physiology, AIIMS Gorakhpur, Uttar Pradesh, India; ³Department of Medicine and Surgery, Amrita School of Medicine, Faridabad, India; ⁴Department of Physiology, KMC Medical College & Hospital, Maharajganj, Uttar Pradesh, India; ⁵Department of General Medicine, Government Medical College, Bhavnagar, India; *Corresponding author

Email

Ankan Mondal - E-mail: jimmiankan@gmail.com
Sangeeta Gupta - E-mail: drsangeeta77.65@rediffmail.com
Aditya Bhattacharjee - E-mail: aadityaa1517@gmail.com
Amrit Podder - E-mail: amritpodder0@gmail.com
Parth Jani - E-mail: parthjani13@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

The need to better understand the role of tumor necrosis factor-alpha (TNF-α) in Alzheimer's disease (AD) and its relationship with brain atrophy and cognitive decline is highly relevant. Therefore, it is of interest to investigate the role of tumor necrosis factor-alpha (TNF-α) in Alzheimer's disease (AD) by analyzing its relationship with brain atrophy and cognitive decline in 80 AD patients. Our results show a significant correlation between increased CSF TNF-α levels and hippocampal atrophy. Additionally, TNF-α level were associated with other clinical variables, emphasizing its role in neuroinflammation. Thus, TNF-α as a potential biomarker for Alzheimer's disease progression. Further research is needed to assess its therapeutic potential. The advancement to knowledge in this study is the identification of a significant correlation between elevated TNF-α levels and hippocampal atrophy in Alzheimer's disease, supporting TNF-α as a potential biomarker for disease progression.

Keywords

Alzheimer's disease, biomarker, cognitive decline, inflammation, tumor necrosis factor-alpha

Citation

Mondal et al. Bioinformation 22(1): 47-50 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.