Title

Effect of chronic stress on human endocrine function: A biomarker-based study

Authors

Ajeet Singh^1,*, Pramod Kumar¹, Hemali Jha², Amrit Podder³ & Parth Jani⁴

Affiliation

¹Department of Physiology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India; ²Department of Internal Medicine, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India; ³Department of Physiology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India; ⁴Department of General Medicine, Government Medical College, Bhavnagar, India; *Corresponding author

Email

Ajeet Singh - E-mail: drajeetaje1234@gmail.com
Pramod Kumar - E-mail: kushdxpk@gmail.com
Hemali Jha - E-mail: dr_hemali@yahoo.co.in
Amrit Podder - E-mail: amritpodder0@gmail.com
Parth Jani - E-mail: parthjani13@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

The impact of chronic stress on endocrine function, particularly its effects on cortisol, thyroid hormones, and sex hormones is of interest. The study employed a cross-sectional design, involving 120 participants (aged 18–60) exposed to chronic stress for 6 months or longer. Elevated cortisol levels and disruptions in thyroid and reproductive hormones were observed, particularly in those experiencing high stress. Data show the potential of biomarkers like thyroid-stimulating hormone (TSH) for monitoring stress-related endocrine dysfunctions. Thus, we show the significant role of chronic stress in hormone dysregulation and its associated health risks. The study offers insights into early detection and therapeutic strategies for stress-related health issues.

Keywords

Cortisol, endocrine dysfunction, hormonal changes, stress biomarkers, thyroid-stimulating hormone

Citation

Singh et al. Bioinformation 22(1): 56-60 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.