Title

Molecular and hormonal mechanisms of male infertility and their clinical implications

Authors

Humaira Alam¹*, Fahmida Zabin², Kazi Farhana Begum², Nigar Sultana² & Taqik A Ibrahim³

Affiliation

¹Department of Reproductive Endocrinology and Infertility, Bangladesh Medical University, Shahbag, Dhaka, Bangladesh; ²Department of Obstetrics and Gynaecology, Bangladesh Medical University, Shahbag, Dhaka, Bangladesh; ³Department of Molecular and Cellular Biology, University of Guelph, Guelph, Canada; *Corresponding author

Email

Fahmida Zabin - E-mail: fahmida.zabin@bsmmu.edu.bd
Kazi Farhana Begum - E-mail: farhanakazi04@bmu.ac.bd
Nigar Sultana - E-mail: nigarsultana@bsmmu.edu.bd
Taqik A Ibrahim - E-mail: taqikibrahim@gmail.com

Humaira Alam - E-mail: humaira.alam@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Male infertility is a pressing health issue in Bangladesh, affecting a significant portion of the male population and necessitating investigation into its underlying molecular and hormonal mechanisms. Therefore, it is of interest to investigate the molecular and hormonal mechanisms underlying male infertility in Bangladesh, a pressing health issue affecting a significant portion of the male population. Hormonal assays and molecular biomarkers, including sperm DNA fragmentation, reactive oxygen species (ROS) and HSP70 expression, were analyzed. Infertile men showed show FSH and LH levels, reduced testosterone and elevated ROS and DNA fragmentation compared to controls. Thus, novel insights into the molecular and hormonal mechanisms contributing to male infertility in Bangladesh specifically highlight the impact of hormonal imbalance and oxidative stress.

Keywords

Male infertility, hormonal imbalance, oxidative stress, sperm DNA fragmentation, Bangladesh

Citation

Alam et al. Bioinformation 22(1): 89-93 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.