Title

An observational study to compare the treatment outcomes of older and newer antiretroviral regimen in HIV patients

Authors

Lovely Lahare¹, Shashi Marko¹, Lily Dubey¹ & Pawan Gupta²,*

Affiliation

¹Department of Pharmacology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ²Department of Dermatology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; *Corresponding author

Email

Lovely Lahare - E-mail: lovelylahare2605@gmail.com

Shashi Marko - E-mail: drshashi0308@gmail.com
Lily Dubey - E-mail: lilydubeyg@gmail.com
Pawan Gupta - E-mail: pawanguptag@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

The need to compare the effectiveness and adverse effects of Dolutegravir-based regimens versus older TLE regimens in HIV treatment is relevant. Therefore, it is of interest to evaluate their comparative outcomes in a clinical setting including 180 adults with HIV. Results showed comparable efficacy in CD4 counts and viral load between the two groups, although Dolutegravir seemed to cause a quicker increase in CD4 counts. This study contributes to the existing body of knowledge by providing direct comparisons of Dolutegravir-based and older TLE regimens in HIV treatment, highlighting both efficacy and safety outcomes, with a specific focus on CD4 count progression and adverse effects.

Keywords

Dolutegravir, CD4 count, viral load, antiretroviral therapy.

Citation

Lahare et al. Bioinformation 22(1): 98-101 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.