Title

An update on articaine use in dentistry

Authors

Genesis Hurtado¹,*, Navdeep Kaur², Visali Priyankitha Bomidi³, Ashmita Kaur Kohli⁴, Tayyaba Hamid⁵ & Fatima Zahid⁶

Affiliation

¹Department of Human Anatomy, School of Dentistry, Central University of Venezuela, Caracas, Venezuela; ²Department of Dental Surgery, Sri Guru Ram Das Institute of Dental Sciences & Research, Amritsar, Punjab, India; ³Department of Dental Surgery, Department of Oral and Maxillofacial Surgery, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India; ⁴Department of Dental Surgery, I.T.S Dental College, Ghaziabad, Murad Nagar, Ghaziabad, Uttar Pradesh, India; ⁵Department of Dental Surgery, Lahore Medical and Dental College, Lahore, Punjab, Pakistan; ⁶Department of Dental Surgery, University of Lahore, Lahore, Punjab, Pakistan; *Corresponding author

Email

Genesis Hurtado - E-mail: oksmez9@gmail.com
Navdeep Kaur - E-mail: 23kaurnavdeep@gmail.com
Visali Priyankitha Bomidi - E-mail: priyankitha.bomidi@gmail.com
Ashmita Kaur Kohli- E-mail: ashmita0023@hotmail.com
Tayyaba Hamid - E-mail: tayyabahamid12@gmail.com
Fatima Zahid - E-mail: Fatima.zahid@gwmail.gwu.edu

Article Type

Views

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Articaine hydrochloride is considered a highly effective and reliable local anesthetic in dentistry owing to its unique pharmacological characteristics. Its thiophene ring and ester group enhance lipid solubility, ensuring rapid tissue diffusion and efficient hydrolysis that limit systemic toxicity. The 4% formulation offers quicker onset, extended pulpal and soft tissue anesthesia and superior bone penetration compared with lidocaine, mepivacaine, and prilocaine. Recent advancements such as buffered formulations, antibacterial modifications and needle-free systems have further broadened its potential applications. This contributes to high procedural efficiency, improved patient comfort and prolonged anesthetic effects.

Keywords

Articaine, dental anesthesia, infiltration, paresthesia, amide

Citation

Hurtado et al. Bioinformation 22(1): 102-106 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.