Title

A retrospective analysis of interobserver variability in 356 cases over a period 10 years: Celiac disease

Authors

Shikha Ghanghoria¹, Arvind Ghanghoria², Tarun Prakash Verma³,*, Aashita Thakur⁴, Gulladurthi Prudhvi Sai Chownika⁴ & Sachin Parmar⁵

Affiliation

¹Department of Pathology, Mahatma Gandhi Memorial Medical College (M.G.M.M.C) and Maharaja Yeshwantrao Hospital (M.Y.H), Indore, Madhya Pradesh, India; ²Department of General Surgery, Mahatma Gandhi Memorial Medical College (M.G.M.M.C) and Maharaja Yeshwantrao Hospital (M.Y.H), Indore, Madhya Pradesh, India; ³Multidisciplinary Research Unit, M.G.M Medical College, Indore, Madhya Pradesh, India; ⁴Department of Pathology, Mahatma Gandhi Memorial Medical College (M.G.M.M.C) and Maharaja Yeshwantrao Hospital (M.Y.H), Indore, Madhya Pradesh, India; ⁵Department Community Medicine, V.K.S. Government Medical College, Neemuch, Madhya Pradesh, India; *Corresponding author

Email

Shikha Ghanghoria - E-mail: amandiagnostic@gmail.com
Arvind Ghanghoria - E-mail: profdrarvindghanghoria@gmail.com
Tarun Prakash Verma - E-mail: tarunverma.tpv@gmail.com
Aashita Thakur - E-mail: aashita.thakur03@gmail.com
Gulladurthi Prudhvi Sai Chownika - E-mail: prudhvigulladurthi@gmail.com
Sachin Parmar - E-mail: dr.sachinparmar@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Celiac disease (CD) is an immune-mediated enteropathy in which dietary gluten triggers a T-cell–driven inflammatory injury of the small-intestinal mucosa in genetically predisposed individuals. Therefore, it is of interest to compare the distribution of the diagnostic categories and the interobserver variation of the Modified Marsh-Oberhuber and Corazza-Villanacci histopathological categories in biopsy-proven celiac disease samples of 356 cases collected in 10 years. All duodenal biopsies were reviewed by two independent pathologists who scored it twice with each of the two systems; Cohen concordance was used as a measure of interobserver agreement. Majority of initial diagnoses were compressed in Marsh III subtypes and recategorization showed significant discordance of Marsh (iii) a to (iii) c, which represents little reproducibility. By contrast, Corazza-Villanacci produced majority of Grade B1 tasks with maximal consensus among pathologists, which was highly reproducible and did not compromise clinically valuable stratification. The results argue in favor of the straightforward implementation of the streamlined Corazza-Villanacci system in Indian high throughput settings to increase the consistency of the diagnoses and standardize patient care.

Keywords

Celiac disease, histopathology, marsh-oberhuber, corazza-villanacci, interobserver agreement

Citation

Ghanghoria et al. Bioinformation 22(1): 137-141 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.