Title

Effect of endotracheal tube cuff pressure on postoperative outcomes in Laparoscopic cholecystectomy

Authors

Mukesh Kumar Prasad¹*, N.K. Singh² & V.K. Singh³

Affiliation

¹Department of Anesthesia, TMMC and RC, Teerthanker Mahveer University, Moradabad, Uttar Pradesh, India; ²Department of Surgery, TMMC & RC, Teerthanker Mahveer University, Moradabad, Uttar Pradesh, India; ³Department of Medicine, TMMC and RC, Teerthanker Mahveer University, Moradabad, Uttar Pradesh, India; *Corresponding author

Email

Mukesh Kumar Prasad - E-mail: drmukeshkumarprasad@gmail.com

N.K. Singh - E-mail: naveenkumar1979singh@gmail.com
V.K. Singh - E-mail: drvinodkumarsingh85@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Despite widespread use of nitrous oxide in laparoscopic cholecystectomy, its impact on endotracheal tube cuff pressure, hemodynamics and postoperative complications remains insufficiently characterized. This study compared the effects of air and nitrous oxide as inflating agents on haemodynamic parameters, postoperative complications and endotracheal tube cuff pressure in patients undergoing laparoscopic cholecystectomy. A total of 148 patients were monitored for intraoperative vital signs and cuff pressures at 30, 60 and 90 minutes. Postoperative issues such as dysphagia, hoarseness and sore throat were assessed immediately and 24 hours after surgery. Nitrous oxide significantly increased cuff pressure (p < 0.001) and was associated with a higher incidence of sore throat (25.68% vs. 9.46%, p = 0.007). These findings highlight the importance of careful cuff pressure monitoring to reduce postoperative complications and ensure patient safety.

Keywords

Endotracheal tube cuff pressure, Nitrous oxide, Hemodynamic changes, Postoperative complication, Laparoscopic cholecystectomy.

Citation

Prasad et al. Bioinformation 22(1): 146-151 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.