Title
Comparative study of serum titanium levels in patients before and after dental implant placement
Authors
Akhilesh Tomar1,*, Akanksha Kashyap2, Rakesh Kumar Roy3, Shubhashree Ghosh3, Vinit Kumar Singh4 & Harpreet Singh Chhabra5
Affiliation
1Department of Periodontics and Implantology, Vananchal Dental College and Hospital, Garhwa, Jharkhand, India; 2Department of Periodontics and Implantology, Babu Banarasi Das college of dental sciences, Lucknow, Uttar Pradesh, India; 3Department of Prosthodontics and Crown & Bridge, Vananchal Dental College and Hospital, Garhwa, Jharkhand, India; 4Department of Orthodontics and Dentofacial Orthopaedics, Vananchal Dental College and Hospital, Garhwa, Jharkhand, India; 5Department of Conservative Dentistry and Endodontics, Sardar Patel Post Graduate Institute of Dental And Medical Sciences, Lucknow, Uttar Pradesh, India; *Corresponding author
Akhilesh Tomar - E-mail: dr.tomarakhilesh82@gmail.com
Akanksha Kashyap - E-mail: anku.kashyap18@gmail.com
Rakesh Kumar Roy - E-mail: rrakesh.kumar.roy@gmail.com
Shubhashree Ghosh - E-mail: shubhashreeghosh1330@gmail.com
Vinit Kumar Singh - E-mail: drvinit.singh@gmail.com
Harpreet Singh Chhabra - E-mail: harryagar@gmail.com
Article Type
Research Article
Date
Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026
Abstract
Titanium (Ti) dental implants are considered the gold standard in edentulous rehabilitation. However, the tribocorrosion and subsequent release of titanium ions into the systemic circulation has become an issue of concern. Hence, this prospective longitudinal study used the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) at baseline, 1-week and 6-months post-operative in order to study serum titanium levels in 60 healthy patients that were undertaking the implant surgery. The baseline serum titanium levels were 1.42 ± 0.55 ng/mL with a statistically significant increase of the mean serum titanium levels to 2.15 + 0.82 ng/mL after one week post-operation and a partial stabilization to 1.94 + 0.71 ng/mL at 6 months. Though, the dental implant placement causes a statistically significant increase in the levels of titanium in the systemic compartments, these levels are far below the accepted toxicological limits.
Keywords
Dental implants, titanium release, systemic absorption, ICP-MS, biocompatibility, tribocorrosion
Citation
Tomar et al. Bioinformation 22(1): 175-179 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
