Title
Triamcinolone acetate and triamcinolone-isotretinoin efficacy in oral lichen planus management: Original clinical study
Authors
Anish Ashok Gupta1,*, R.M. Vatchala Rani2, G.A. Prarthana3, Vaibhavi Mehta4, Monika Tanwar5 & Santosh Kumar6
Affiliation
1Department of Oral Pathology & Microbiology, People's Dental Academy, People's University, Bhopal, Madhya Pradesh, India; 2Department of Oral pathology and Microbiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India; 3Department of Oral medicine and Radiology, Rajarajeswari Dental College and Hospital, Bangalore, Karnataka, India; 4Department of Oral Medicine and Radiology, K.M. Shah Dental College and Hospital, Sumandeep Vidhyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, India; 5Department of Oral and Maxillofacial Surgery, SGT University, Gurgaon, Haryana, India; 6Department of Periodontology & Implantology, Karnavati University, Uvarsad, Gandhinagar, Ahmedabad, Gujarat, India; *Corresponding author
Anish Ashok Gupta - E-mail: anishpooja687@yahoo.co.in
R.M. Vatchala Rani - E-mail: rvatchala@jmi.ac.in
G.A. Prarthana - E-mail: prarthanaga7@gmail.com
Vaibhavi Mehta - E-mail: vaibhavishukla69@gmail.com
Monika Tanwar - E-mail: monikaapril1992@gmail.com
Santosh Kumar - E-mail: santoshkumar@karnavatiuniversity.edu.in
Article Type
Research Article
Date
Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026
Abstract
Oral lichen planus (OLP) is a long-term inflammatory mucocutaneous disease that has the potential of malignant transformation. Hence, it requires effective long-term therapy. It was a randomized controlled, double-blind trial comparing triamcinolone acetonide 0.1 per cent oral paste (TA) to TA once daily with oral isotretinoin 10mg daily (TA+ISO) in 70 cases (biopsy-established) of OLP of more than 12 weeks duration. The TA+ISO group showed better clinical outcomes as the means of Thongprasom scores reduced in the TA group (p<0.001). TA+ISO showed more pain reduction (VAS) at 12 weeks (p<0.001), improved Histopathological (74.3) TA+ISO (p=0.006) and reduced Lesion size (p<0.001). TA in combination with isotretinoin is very useful as combination therapy in OLP and clinical and histopathological results are improved.
Keywords
Oral lichen planus, triamcinolone acetonide, isotretinoin, combination therapy, Thongprasom score, malignant potential
Citation
Gupta et al. Bioinformation 22(1): 201-205 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
