Title

Treatment outcomes and clinical characteristics in diabetic versus non-diabetic sinonasal tuberculosis

Authors

Praveen Kumar Tagore¹ & Mahendra Kumar Bharti^2,* & Manish Kumar Sachan³

Affiliation

¹Department of General Medicine, Government Medical College, Datia, Madhya Pradesh, India; ²Department of TB & Chest, Government Medical College, Datia, Madhya Pradesh, India; ³Department of Ear Nose Throat, Government Medical College, Datia, Madhya Pradesh, India; *Corresponding author

Email

Praveen Kumar Tagore - E-mail: tagore.praveen@gmail.com
Mahendra Kumar Bharti - E-mail: bharti.niw@gmail.com

Manish Kumar Sachan- E-mail: manish29.sachan@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Sinonasal tuberculosis (SNTB) is a rare extrapulmonary presentation with poorly understood interplay with diabetes mellitus (DM). Therefore, it is of interest to compare the clinical presentation, microbiological characteristics and treatment outcomes between 60 patients with DM with SNTB and 60 non-diabetic controls treated in one of the tertiary referral centers. DM patients had a longer duration of symptoms (18.4±6.2 vs 11.2±4.1 weeks, p=0.001), more complications (41.7% vs 18.3% p=0.004) and more disease on imaging (bony involvement: 55.0% vs 31.7, p=0.011). The culture positivity (78.3 vs 58.3, p=0.015) and drug resistance (multidrug-resistance: 15.0 vs 3.3, p=0.026) were more positive in microbiologically positive patients of DM. The results of treatment showed slower conversion of sputum in DM patients (8.3±2.1 vs 6.1±1.8 weeks, p<0.001), longer therapy period (9.8±1.2 vs 8.2±0.9 months, p<0.001) and reduced success rates (78.3% vs 91.7, p=0.032). Thus, outcome success was negatively related to glycemic control (r= -0.67, p=0.001).

Keywords

Sinonasal tuberculosis; diabetes mellitus; extrapulmonary tuberculosis; treatment outcomes; drug resistance; clinical profile

Citation

Tagore et al. Bioinformation 22(1): 206-210 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.