Title

Diagnostic treatment modalities premalignant oral lesions oral cancer progression impact: Comparative study

Authors

Sandeep Sidhu¹, Kumari Priyanka Shrivastava¹, Hershita Singh^2,*, Ametesh Dutta³, Apoorva Ravi Sondh⁴ & Mamta Sharma⁵

Affiliation

¹Department of Oral Pathology and Microbiology, Maharaja Ganga Singh Dental college and Research Centre, Sriganganagar, Rajasthan, India; ²Department of Oral Pathology and Microbiology, National Dental College, Derabassi, Mohali, Punjab, India; ³Department of Oral Pathology and Microbiology, Gian Sagar Dental College and Hospital, Ram Nagar, Rajpura, Punjab, India; ⁴Department of Oral and Maxillofacial Pathology and Oral Microbiology, Swami Devi Dyal Hospital and Dental College, Golpura, Barwala, Panchkula, Haryana, India; ⁵Department of Oral Pathology and Microbiology, Rajasthan Dental college and Hospital, Jaipur, Rajasthan, India; *Corresponding author

Email

Sandeep Sidhu - E-mail: dr.sandeepsidhu30@gmail.com
Kumari Priyanka Shrivastava - E-mail: Priyanka015tu@gmail.com
Hershita Singh - E-mail: drhershitas@gmail.com
Ametesh Dutta - E-mail: 32rockstar32@gmail.com
Apoorva Ravi Sondh - E-mail: apoorvasondh.18@gmail.com
Mamta Sharma - E-mail: drmamta.jpr@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

The best management of the oral potentially malignant disorders (OPMDs) remains uncertain particularly when subdivided into the levels of dysplasia. This retrospective cohort study involved 200 cases of patients who were compared with regard to malignant transformation and recurrence of malignancies between surgical excision and active surveillance. It was established that surgical excision had a substantially lower transformation risk, especially in moderate-to-severe dysplasia and had better malignancy-free survival on KaplanMeier analysis. Repeated cases were seen in both groups, but surveillance and high-grade dysplasia were found to be an independent powerful predictor of malignant progression. Thus, surgical excision offers meaningful protection in the transforming process and should be given priority with high-risk OPMDs to minimise the transition to OSCC.

Keywords

Oral potentially malignant disorders, oral cancer, leukoplakia, surgical excision, malignant transformation, dysplasia

Citation

Sidhu et al. Bioinformation 22(1): 211-215 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.