Title

Comparative evaluation of tissue adhesives and conventional sutures in periodontal flap surgery: A randomized clinical study

Authors

Ankita Garg¹*, Preksha Agrawal², Geeta Tripathi¹ & Gaurav Jain³

Affiliation

¹Department of Dentistry, Shyam Shah Medical College, Rewa, Madhya Pradesh, India; ²Department of Obstetrics and Gynaecology, Shri Ramkrishna Institute of Medical Sciences and Sanaka Hospitals, Durgapur, West Bengal, India; ³Department of Pulmonology and Sleep Medicine, Batra Hospital and Medical Research Centre, New Delhi, India; *Corresponding author

Email

Ankita Garg - E-mail: anky14.ag@gmail.com
Preksha Agrawal - E-mail: agrawalpreksha40@gmail.com
Geeta Tripathi - E-mail: geeta.tripathi75@gmail.com
Gaurav Jain - E-mail: Gjain.doc@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Post-surgical discomfort, delayed soft tissue healing and risk of infection remain significant challenges associated with conventional suturing methods in periodontal flap surgeries. Therefore, it is of interest to evaluate four different groups (n=10 each); Group 1 – silk sutures, Group 2 – vicryl sutures, Group 3 – fibrin sealant (Tisseel) and Group 4 – isoepoxy 2-cyanoacrylate adhesives (Amcrylate) and compared effects on wound healing, postoperative discomfort and clinical outcomes in periodontitis patients. Phase I therapy was followed by full-thickness mucoperiosteal flaps elevation, debridement and closure conducted as specified. The measurement of healing was done at 1, 2, 4 and 12 weeks by the use of Landry Healing Index, Visual Analog Scale (VAS) of pain, Plaque and Gingival Indices, Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL). Tissue glues, especially fibrin-based sealants, provided periodontal flap closure with clinically reliable, biocompatible and patient-friendly option which enhances faster hemostatic and early healing.

Keywords

Periodontal surgery; tissue adhesive; cyanoacrylate; fibrin sealant; sutures; wound healing; tisseel; amcrylate

Citation

Garg et al. Bioinformation 22(1): 241-244 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.