Title

Serum lipid profile patterns in patients with oral cancer and oral potentially malignant disorders

Authors

Priyanka Singh¹, Sangeeta Gupta^2,*, Gaurav Gupta³, Deepika Patidar⁴, Dinesh Patidar⁵ & Ishita Gupta⁶

Affiliation

¹Department of Oral Medicine and Radiodiagnosis, K. M. Shah Dental College, Sumandeep Vidyapeeth University, aghodiya, Vadodara, Gujarat, India; ²Department of Physiology, All India Institute of Medical Sciences (AIIMS), Gorakhpur, Uttar Pradesh, India; ³Department of General Surgery, All India Institute of Medical Sciences (AIIMS), Gorakhpur, Uttar Pradesh, India; ⁴Department of Pedodontics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India; ⁵Department of Trauma and Emergency, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India; ⁶Government Institute of Medical Sciences, Noida, Uttar Pradesh, India; *Corresponding author

Email

Priyanka Singh - E-mail: piyasingh290@gmail.com
Sangeeta Gupta - E-mail: drsangeeta77.65@rediffmail.com, drsangeetag@aiimsgorakhpur.edu.in
Gaurav Gupta - E-mail: drgaurav75@rediffmail.com, drgauravg@aiimsgorakhpur.edu.in
Deepika Patidar - E-mail: drdeepika.prasad@gmail.com
Dinesh Patidar - E-mail: drdineshpatidar.30@gmail.com
Ishita Gupta - E-mail: vib16ish@rediffmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

The role of serum lipids as tumour markers in the diagnosis of oral cancer and oral potentially malignant disorders (OPMDs) is of interest. Hence, three groups (oral cancer, OPMDs and age and sex matched healthy controls) comprising 40 patients each was selected. Serum lipid profile values (total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein and very low density lipoprotein) were compared among the groups (unpaired t-test and one way-ANOVA) (p-value of <0.05 was considered as significant). Mean values of total serum cholesterol and low density lipoprotein were found to be elevated in cases of oral cancer and oral PMDs as compared to controls with statistical significance (p<0.001). The alterations in levels obtained in the study, support the role of serum lipid profile as biomarkers for oral cancer and OPMDs, yet strengthening of the evidences by long-term follow-up studies with larger sample sizes are warranted to establish the association.

Keywords

Oral cancer, oral potentially malignant disorders, lipid, cholesterol, triglycerides, low density lipoprotein, high density lipoprotein and very low density lipoprotein.

Citation

Singh et al. Bioinformation 22(1): 328-332 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.