Title
Comparative evaluation of open flap debridement with or without injectable platelet-rich fibrin in chronic periodontitis treatment
Authors
Sakshi Verma, Vandana Sarangal*, Supreet Kaur, Sahib Tej Singh, Vidhuta Sareen, Simranjit Kaur & Simrita Singh
Affiliation
Department of Periodontology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India; *Corresponding author
Sakshi Verma - E-mail:
vermasakshi431@gmail.com
Vandana Sarangal - E-mail: drvandana6@gmail.com
Supreet Kaur - E-mail: drsupreet2000@yahoo.co.in
Sahib Tej Singh - E-mail: sahibtejsingh@yahoo.com
Vidhuta Sareen - E-mail: drvidhutasareen@gmail.com
Simranjit Kaur - E-mail: dr.simrank26@gmail.com
Simrita Singh - E-mail: simritasingh2014@gmail.com
Article Type
Research Article
Date
Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026
Abstract
Periodontitis, particularly generalized Stage III Grade B periodontitis with intrabony defects, presents significant challenges in treatment, requiring innovative adjunctive therapies to enhance the effectiveness of conventional treatments such as open flap debridement (OFD). Hence, twenty-four patients were randomized to receive OFD alone or OFD + i-PRF. The results showed significant improvements in clinical parameters and radiographic defect fill at 6 months in i-PRF group. I-PRF demonstrated superior outcomes in probing pocket depth reduction and relative attachment level gain. It offers a promising, biocompatible, cost-effective approach for periodontal regeneration. Thus, the of effect i-PRF's as an adjunct to open flap debridement, showing significant improvements in clinical and radiographic outcomes for Stage III Grade B periodontitis with intrabony defects is reported.
Keywords
Periodontitis, platelet-rich fibrin, open flap debridement, intrabony defects, regenerative therapy
Citation
Verma et al. Bioinformation 22(1): 436-442 (2026)
Edited by
Ritik Kashwani
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
