Title

Intralesional triamcinolone versus 5-fluorouracil for keloids and hypertrophic scars: A randomized comparative clinical study

Authors

Anubhav Sharma¹*, T. Thirumalaiswamy², Amulya Singirikonda³, K Prameela, B Supritha Patil⁵, Alekhya Achanta⁶ & Shan Nawaz Malik⁷

Affiliation

¹Department of Orthopedics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India; ²Department of General Surgery, Dhanalakshmi Srinivasan Medical College & Hospital, Siruvachur, Chennai–Trichy National Highway, Perambalur, Tamil Nadu, India; ³Department of dental surgery, Mamata Dental College and Hospital, Khammam, Telangana, India; ⁴Department of Oral Medicine and Radiology, Mallareddy Dental College for Women, Malla Reddy Vishwavidyapeeth, Suraram, Hyderabad, Telangana, India; ⁵Department of Oral Medicine and Radiology, Tirumala Institute of Dental Sciences and Research Centre, Nizamabad, Telangana, India; ⁶Department of Paediatric and Preventive Dentistry, Malla Reddy Institute of Dental Sciences, Malla Reddy Vishwavidyapeeth, Suraram, Hyderabad, Telangana, India; ⁷Department of Dentistry, Dental Clinician, London, United Kingdom; *Corresponding author

Email

Anubhav Sharma - E-mail: dranubhavsharma007@gmail.com

T. Thirumalaiswamy - E-mail: tthirumalaisamy@yahoo.com

Amulya Singirikonda - E-mail: asingiri@outlook.com

K Prameela - E-mail: prameelakhetavath@gmail.com

B. Supritha Patil - E-mail: patilsupi25@gmail.com
Alekhya Achanta - E-mail: alekhya8692.a@gmail.com

Shan Nawaz Malik - E-mail: shanawaz_mlk@yahoo.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Keloids and hypertrophic scars lack a consistently effective and safe intralesional treatment and direct randomized comparisons between triamcinolone acetonide and 5-fluorouracil remain limited. Therefore, it is of interest to randomize clinical trial compared both agents in 100 patients treated over 12 weeks, evaluating scar height reduction, symptom improvement and adverse effects. Both treatments achieved significant scar flattening, with triamcinolone showing marginally greater mean height reduction. However, triamcinolone was associated with substantially higher rates of skin atrophy and telangiectasia, while 5-fluorouracil demonstrated a superior safety profile. Thus, we show 5-fluorouracil as a suitable first-line option for keloids and hypertrophic scars, especially in cosmetically sensitive areas.

Keywords

Keloid; hypertrophic scars; intralesional injection; triamcinolone acetonide; 5-fluorouracil

Citation

Sharma et al. Bioinformation 22(1): 461-464 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.