Title

Multifaceted benefits of xylitol in oral health: from caries prevention to periodontal therapy

Authors

Nidhiswi Yeruva¹,*, Luisana Rodriguez², Melania Romero³, Anjali Aryal⁴, Leonardo Acosta Pina⁵ & Mihriban Sayğı⁶

Affiliation

¹Department of Dental Surgery, Kamineni Institute of Dental Sciences, Nalgonda, India; ²Department of Dental Surgery, School of Dentistry, University of Carabobo, Naguanagua-Venezuela; ³Department of Dental Surgery, School of Dentistry, University of Zulia, Maracaibo-Venezuela; ⁴Department of Dental Surgery, City Dental College, University of Dhaka, Dhaka-Bangladesh; ⁵Department of Dental Surgery, School of Dentistry, University Santa Maria, Caracas-Venezuela; ⁶Department of Dental Surgery, Necmettin Erbakan University Faculty of Dentistry, Konya/ Turkey; *Corresponding author

Email

Nidhiswi Yeruva - E-mail: Reddynidhi498@gmail.com
Luisana Rodriguez - E-mail: Lrodriguezc.dds@gmail.com
Melania Romero - E-mail: melaniaromeros@gmail.com
Anjali Aryal - E-mail: anjaliaryal107@gmail.com
Leonardo Acosta Pina - E-mail: odleonardo@gmail.com
Mihriban Sayğı - E-mail: mhrbnsyg@gmail.com

Article Type

Research Article

Date

Received January 1, 2026; Revised January 31, 2026; Accepted January 31, 2026, Published January 31, 2026

Abstract

Xylitol, a naturally occurring sugar alcohol, exhibits multifaceted benefits in dentistry, including inhibition of cariogenic bacteria, suppression of biofilm formation and stimulation of salivary flow. Therefore, it is of interest to review synthesizes current evidence on its role in caries prevention, periodontal therapy and management of xerostomia, candidiasis and halitosis. Clinical and public health implications have been discussed, with emphasis on optimal dosage, delivery methods and integration into preventive strategies. Emerging evidence highlights its relevance as a safe and adjunctive modality within evidence-based preventive and therapeutic protocols. Future studies should include rigorously designed randomized controlled trials and translational studies to establish standardized guidelines for integrating it into clinical practice and community-based oral health programs.

Keywords

Xylitol, dental caries prevention, periodontal therapy, xerostomia, oral health promotion

Citation

Yeruva et al. Bioinformation 22(1): 588-592 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.