Title

Global longitudinal strain for early detection of subclinical left ventricular systolic dysfunction in patients with systemic lupus erythematosus at a tertiary care centre: A hospital-based study

Authors

Krati Mishra^1,*, Vinod Khandait¹, Kaustubh Telang², Suresh Sarwale³, Dheeraj Karde³ & Saransh Barai¹

Affiliation

¹Department of Medicine, GMCH Nagpur, India; ²Department of Rheumatology, SSH Nagpur, India; ³Department of Cardiology, SSH Nagpur, India; *Corresponding author

Email

Krati Mishra - E-mail: kmtt30@gmail.com
Vinod Khandait - E-mail: drkhandait@rediffmail.com
Kaustubh Telang - E-mail: kaustubhtelang@gmail.com
Suresh Sarwale - E-mail: sureshsarwale21@gmail.com
Dheeraj Karde - E-mail: karde.dheeraj@gmail.com
Saransh Barai - E-mail: saranshbarai7@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Systemic Lupus Erythematosus (SLE) silently affects cardiac function, requiring early myocardial dysfunction detection to prevent morbidity. This hospital-based cross-sectional study assessed 49 SLE patients (2019 ACR/EULAR criteria) via clinical exam, Electrocardiogram (ECG) and echocardiography including speckle-tracking Global Longitudinal Strain (GLS). Evaluated parameters included Left Ventricular Ejection Fraction (LVEF), diastolic function, valvular lesions, pericardial effusion, pulmonary pressures and GLS (values < -16% indicating subclinical systolic dysfunction). Abnormal GLS occurred in 55.1%, with 28.5% showing preserved LVEF but impaired GLS, alongside systolic dysfunction (63.2%) and diastolic dysfunction (14.2%). GLS advances SLE cardiac screening by detecting subclinical LV impairment before LVEF decline, enabling timely intervention in preserved ejection fraction patients.

Keywords

Systemic lupus erythematosus (SLE), global longitudinal strain (GLS), subclinical systolic dysfunction, echocardiography, speckle tracking, left ventricular function

Citation

Mishra et al. Bioinformation 22(2): 646-650 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.