Title

Linking AKIN stages with tropical infection induced acute kidney injury among Indian patients

Authors

Sharanya Kandaswamy¹, Moneshaa Srinivasan², Preethi Sekar¹, Jeevithan Shanmugam³ & Kaushik Gowthaman^4,*

Affiliation

¹Department of Pathology, KMCH Institute of Health Sciences and Research, Coimbatore, India; ²Department of General Medicine, Sri Venkateshwaraa Medical College Hospital and Research Centre, Ariyur, Pondicherry, India; ³Department of Community Medicine, KMCH Institute of Health Sciences and Research, Coimbatore, India; ⁴Consultant Neurologist, Kumaran Medical Center, Coimbatore, India; *Corresponding author

Email

Sharanya Kandaswamy - E-mail: drsharanyakkaushik@gmail.com

Moneesha Srinivasan - E-mail: moneshaasrinivasan@gmail.com

 Preethi Sekar - E-mail: drpreethisekar@kmchihsr.edu.in

Jeevithan Shanmugam - E-mail: dr.jeevithan@gmail.com

Kaushik Gowthaman - E-mail: kaushikgowthaman@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Tropical acute febrile illness often causes AKI in India and outcome linkage with AKIN staging is still limited. Hence, we studied 150 adults with tropical infection related AKI staged by AKIN at 48 hours and followed till discharge or death. Leptospirosis was the main cause and higher AKIN stage showed more oliguria organ dysfunction longer stay higher dialysis need with mortality rising to 40.9% in stage III. This study adds a clear stage based risk gradient plus simple bedside red flags and basic labs for early triage and it supports timely aggressive support and dialysis referral to reduce avoidable deaths.

Keywords

Acute kidney injury (AKI), tropical febrile illness, leptospirosis, dengue, scrub typhus, AKIN criteria, renal failure, mortality predictors

Citation

Kandaswamy et al. Bioinformation 22(2): 739-743 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.