Title

Comparative assessment of injectable platelet-rich fibrin versus concentrated growth factor for periodontal intrabony defects

Authors

Yasir S. Khan¹, Rishiraj Singh Karki², Tanu Sahney³, Shahrukh Khan³, Varanasi Haripriya^4,* & Pritam Bora⁵

Affiliation

¹Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India; ²Department of Dentistry, Government Doon Medical College and Hospital, Dehradun, India; ³Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow , Uttar Pradesh, India; ⁴Clinical Practioner, Sri Visweswara Dental Care and Implant Centre, Vishakhapatnam Andhra Pradesh, India; ⁵Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow , Uttar Pradesh, India; * Corresponding author

Email

Yasir S. Khan - E-mail: yasirk11@gmail.com
Rishiraj Singh Karki - E-mail: Drrishirajkarki@gmail.com
Tanu Sahney - E-mail: tanu.sahney910@gmail.com.
Shahrukh Khan - E-mail: shahrukhkhan107@gmail.com
Varanasi Haripriya - E-mail: varanasiharipriya95@gmail.com
Pritam Bora - E-mail: prtmbora@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Periodontal intrabony defects present a therapeutic challenge and direct clinical evidence comparing injectable platelet-rich fibrin (i-PRF) and concentrated growth factor (CGF) as regenerative materials remains limited. This randomized controlled split-mouth clinical trial included 20 patients with 40 comparable three-wall intrabony defects treated by open flap debridement followed by either i-PRF or CGF, with clinical and radiographic parameters evaluated at baseline and 6 months. Both groups showed significant improvements in probing pocket depth, clinical attachment level and radiographic defect fill at 6 months (p<0.001). The CGF group demonstrated significantly greater pocket depth reduction, attachment gain and percentage of radiographic defect fill compared with the i-PRF group (p<0.05). Within the limitations of this study, both materials were effective, although CGF exhibited superior regenerative outcomes and may represent a more predictable option for periodontal intrabony defect regeneration.

Keywords

Periodontitis, intrabony defects, periodontal regeneration, injectable platelet-rich fibrin (i-PRF), concentrated growth factor (CGF), randomized controlled trial

Citation

Khan et al. Bioinformation 22(2): 824-828 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.