Title

Transfusion requirements in acute coronary syndrome patients undergoing thrombolysis or anticoagulation: A retrospective cohort study

Authors

Subhash Chandra¹, Varun Singh Sisodia², Prachi Jain Rai¹, Aaditya Shivhare^3,* & Nouratan Singh³

Affiliation

¹Department of Cardiology, UPUMS, Saifai, Etawah, India; ²Department of CTVS, UPUMS, Saifai, Etawah, India; ³Department of Transfusion Medicine, UPUMS, Saifai, Etawah, India; *Corresponding author

Email

Subhash Chandra - E-mail: dr.subhchandra@gmail.com; cardiology.upums22@gmail.com
Varun Singh Sisodia - E-mail: varun1280@gmail.com
Prachi Jain Rai - E-mail: prachijainpj93@gmail.com
Aaditya Shivhare - E-mail: aadityashivhare@gmail.com; aaditya.shiv@upums.ac.in
Nouratan Singh - E-mail: nouratansingh@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Bleeding complications and associated transfusion requirements remain a significant concern in patients with Acute Coronary Syndrome (ACS) undergoing anticoagulation or thrombolysis, yet data on transfusion needs and risk factors in resource-limited settings are limited. Therefore, it is of interest to assess transfusion requirements in 85 patients with Acute Coronary Syndrome (ACS) undergoing anticoagulation or thrombolysis at UPUMS, Saifai, from December 2024 to April 2025. Major bleeding requiring transfusion occurred in 4.7% (n=4) of patients, predominantly due to gastrointestinal sources (50%). The mean transfusion requirement was 2 units of packed red blood cells per bleeding event. Independent risk factors for major bleeding were age >65 years, chronic kidney disease and triple therapy (antiplatelet + anticoagulant + fibrinolytic). Bleeding was associated with significantly higher 30-day mortality (25% versus 5% in non-bleeders), highlighting the need for individualized antithrombotic strategies in ACS management.

Keywords

Acute Coronary Syndrome (ACS); anticoagulation, thrombolysis; chronic kidney disease; therapeutic strategies

Citation

Chandra et al. Bioinformation 22(2): 869-874 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.