Title

TGL / HDL - C ratio and non-HDL-C - prognostic index in chronic kidney disease

Authors

I. Siva¹, G. Chitra Siva Sankari^2,*, Vishaalpalaniswamy Ramaswamy¹, Amuthavalli Vasudevan¹ & K. Pramila¹

Affiliation

¹Institute of Biochemistry, Madras Medical College & Rajiv Gandhi Government General Hospital, TN MGR University Chennai, India; ²Department of Biochemistry, Government Theni Medical College & Hospital, Theni, Tamil Nadu MGR University, Chennai, India; *Corresponding author

Email

I. Siva - E-mail: sivaipsa8488@gmail.com
G. Chitra Siva Sankari - E-mail: drmcvk7896@gmail.com
Vishaalpalaniswamy Ramaswamy - E-mail: drvishaalpalaniswamy08@gmail.com
Amuthavalli Vasudevan - E-mail: amuthamd@gmail.com
K. Pramila - E-mail: dr.k.pramila@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Dyslipidemia, a major risk factor for chronic kidney disease (CKD) affects more than ten percent of the general population. Dyslipidemia in CKD, if left untreated, will result in end stage renal disease. So, the relationship between atherogenic lipid profile ratios and the assessment of CKD severity is a potential area still to be explored. In assessing the severity of CKD, these ratios have higher prognostic value than individual parameters alone. Therefore, it is of interest to evaluate the role of TGL/HDL- c ratio and NON- HDL-c levels in assessing the disease severity in CKD. Cross-sectional study with one hundred and thirteen CKD patients divided into two groups based-on e-GFR levels and CKD-EPIDEMIOLOGY Staging. Quantitative measurements of lipid profile parameters (total cholesterol, triglycerides, HDL-c) done by enzymatic colorimetric method and renal function test by spectrophotometric method. TGL: HDL-c and NON- HDL-c levels were calculated, Statistical data analyzed using SPSS version software 16.0 showed TGL / HDL- c ratio and NON-HDL-c values has significant correlation with CKD staging and found to highly significant (p <0.001). TGL / HDL-c ratio and NON-HDL-c value can be used as a prognostic index in CKD patients.

Keywords

Chronic kidney disease (CKD), Dyslipidemia

Citation

Siva et al. Bioinformation 22(2): 875-879 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.