Title

HER2/neu and Ki-67 as prognostic biomarkers in urothelial carcinoma

Authors

Anamika Rawat¹, Himanshu Joshi², Nishant Mitra³ & Rashmi Bhardwaj^4,*

Affiliation

¹Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India; ²Department of Pathology, Uttar Pradesh University of Medical Sciences (U.P.U.M.S.), Saifai, Etawah, Uttar Pradesh, India; ³Department of Pathology, ESIC Model Hospital, Basai Darapur, Delhi, India; ⁴Department of Anatomy, Shri Siddhi Vinayak Medical College and Hospital, Sambhal, Uttar Pradesh, India; *Corresponding author

Email

Anamika Rawat - E-mail: dr.anamikasingh1602@gmail.com Himanshu

 Joshi - E-mail: drhimanshu1987@gmail.com

Nishant Mitra - E-mail: nishantmitra.alma@gmail.com

Rashmi Bhardwaj - E-mail: dr.rashmibhardwaj.anatomy@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

The prognostic significance of Her2/neu and Ki-67 expression remains insufficiently defined in urothelial carcinoma even though it constitutes a major proportion of malignancies in the male population of the United States and India. Therefore, it is of interest to evaluate Immunohistochemical (IHC) expression of HER2/neu and Ki-67 to correlate with clinicopathological parameters in thirty histologically confirmed cases of urothelial carcinoma in an Indian cohort. We show that the overexpression of HER2/neu and Ki-67 correlates positively with higher tumor grade, advanced stage and may serve as reliable prognostic biomarkers thus guiding therapeutic decision making in management of urothelial carcinoma.

Keywords

Immunohistochemistry (IHC), trans-urethral resection of bladder tissue (TURBT), urothelial carcinoma

Citation

Rawat et al. Bioinformation 22(2): 885-888 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.