Title

Dynamic changes in liquid biopsy markers during OSCC treatment: A longitudinal study

Authors

Amit Kumar Joseph^1,*, Gaurav Khatri², Surapaneni Keerthi Sai³, Tejashwini Kotian⁴ & Shoab Nazir⁵ & Halima Zakir⁵

Affiliation

¹Department of Oral & Maxillofacial Pathology and Oral Microbiology, Teerthanker Mahaveer Dental College & Research Centre, Moradabad, Uttar Pradesh, India; ²Department of ENT and Head Neck Surgery, Medanta-The Medicity, Gurugram, Haryana, India; ³Department of Oral & Maxillofacial Pathology and Oral Microbiology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India; ⁴Department of Pathology, Faculty of Medicine, Manipal University College Malaysia, Bukit Baru, Malacca, Malaysia; ⁵Department of Oral & Maxillofacial Pathology and Oral Microbiology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India; *Corresponding author

Email

Amit Kumar Joseph - E-mail: amit.dental@tmu.ac.in
Gaurav Khatri - E-mail: gauravkhatri333@gmail.com
Surapaneni Keerthi Sai - E-mail: keethu.surapaneni@gmail.com
Tejashwini Kotian - E-mail: 02tejk@gmail.com
Shoab Nazir - E-mail: shoabnazir62@gmail.com
Halima Zakir - E-mail: halimazakkir@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Oral Squamous Cell Carcinoma (OSCC) is often diagnosed at an advanced stage, leading to poor prognosis and limited treatment options. Traditional diagnostic methods are invasive and lack real-time monitoring capabilities. Therefore, it is of interest to investigate the dynamic changes in liquid biopsy markers circulating tumor deoxyribonucleic acid (ctDNA), circulating tumor cells (CTCs), exosomes and micro ribonucleic acids (microRNA) during OSCC treatment. Thus, we show that these markers can effectively monitor treatment response and predict survival outcomes. This research advances the knowledge of liquid biopsies as a non-invasive tool for personalized OSCC management and early relapse detection.

Keywords

circulating tumor DNA, circulating tumor cells, extracellular vesicles, micro ribonucleic acids, oral squamous cell Carcinoma (OSCC)

Citation

Joseph et al. Bioinformation 22(2): 1198-1202 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.