Title

Comparison of hyaluronic acid, chlorhexidine and persica during SRP

Authors

Neeraj Chandra^1, *, Mutyala Swati², Lawanya Chandrakar³, Akshay A. Katara⁴, Astha Shrivastava⁵ & Dharmen Bhansali⁵

Affiliation

¹Department of Periodontics, Institute of Dental sciences, Bareilly, Uttar Pradesh, India; ²Department of Dental Surgery, Surabhi Institute of Medical Sciences, Mundrai, Telangana, India; ³Department of Periodontics, Shri Balaji Institute of dental science, Raipur, Chhattisgarh, India; ⁴Department of Dental Surgery, Specialist Dentist (Orofacial Pain), Dentistry, Omni Family Health, Bakersfield, California, United States; ⁵Department of Oral Medicine, Diagnosis and Radiology, Rungta College of Dental Sciences and Research, Bhilai, Chhattisgarh, India; *Corresponding author

Email

Neeraj Chandra - E-mail: dr.neeraj.chandra05@gmail.com

 Mutyala Swati - E-mail: swatimutyala.mds@gmail.com

 Lawanya Chandrakar - E-mail: lawanya93@gmail.com

Akshay A. Katara - E-mail: akshaykatara26@gmail.com

 Astha Shrivastava - E-mail: asshrivastava.astha@gmail.com

 Dharmen Bhansali - E-mail: drdbhansali@gmail.com

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

The optimal choice of local drug delivery agents for chronic periodontitis treatment remains uncertain. This study compared 0.8% hyaluronic acid (HA), 0.2% chlorhexidine (CHX) and 10% Salvadora persica (SP) gels versus SRP alone in stage I and II chronic periodontitis patients. 100 patients were randomized into four groups: HA gel, CHX gel, SP gel and SRP alone. Results showed significant clinical improvement with HA showing superior wound healing, CHX having the best antimicrobial effects but higher side effects and SP demonstrating minimal side effects with adequate antimicrobial potential. This study contributes to the understanding of the efficacy and safety of different local drug delivery agents, offering guidance for periodontists in clinical practice.

Keywords

hyaluronic acid (HA), chlorhexidine (CHX), Salvadora persica (SP), scaling and root planing (SRP), gingivitis, anti inflammatory

Citation

Chandra et al. Bioinformation 22(2): 1212-1215 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.