Title

Comparative evaluation of diode laser fibrotomy versus intralesional dexamethasone plus hyaluronidase for moderate oral submucous fibrosis

Authors

Vani Chappidi^1,*, Nagaraju Kamarthi¹, Farah Vaqar Ahmed Momin², Dheeraj Voulligonda³ & Naseer Mohammad⁴

Affiliation

¹Department of Oral Medicine and Radiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India; ²Department of Periodontology, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India; ³Department of Oral Medicine and Radiology, Mamata Institute of Dental Sciences, Bachupally, Hyderabad, Telangana, India; ⁴Department of Oral and Maxillofacial Surgery, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India; *Corresponding author

Email

Vani Chappidi - E-mail: drvanichappidi@gmail.com; Phone: +91 9849995614
Nagaraju Kamarthi - E-mail: drnagrani1977@gmail.com; Phone: +91 9720114173
Farah Vaqar Ahmed Momin - E-mail: farahmomin11@gmail.com; Phone: +91 9000512911
Dheeraj Voulligonda - E-mail: dheerajroy45@gmil.com; Phone: +91 8754536432
Naseer Mohammad - E-mail: dr.naseerm@gmail.com; Phone: +91 9949004204

Article Type

Research Article

Date

Received February 1, 2026; Revised February 28, 2026; Accepted February 28, 2026, Published February 28, 2026

Abstract

Oral submucous fibrosis (OSMF) represents a chronic, progressive, potentially malignant disorder lacking consensus on optimal management strategies for moderate clinical stages. Therefore, it is of interest to compare diode laser fibrotomy (Group A) versus intralesional dexamethasone sodium phosphate plus hyaluronidase (Group B) in 30 patients with moderate (Group II–III) OSMF. Mouth opening and cheek flexibility measurements at baseline, 1, 3 and 6 months revealed statistically significant intragroup improvements in both groups (p < 0.001). Intergroup analysis demonstrated significantly greater functional gains with laser fibrotomy compared to intralesional therapy (p < 0.001), highlighting superior clinical efficacy. Thus, we show OSMF management by establishing diode laser fibrotomy as a minimally invasive, highly effective treatment option for moderate disease stages.

Keywords

Oral submucous fibrosis (OSMF), diode laser, fibrotomy, intralesional steroids, hyaluronidase

Citation

Chappidi et al. Bioinformation 22(2): 1239-1243 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.