Title

Comparative evaluation of non-surgical and surgical treatment modalities for oral cancer

Authors

Akhil Trivedi^1,*, J.K Savita², Mayuri Jain³, Devashree Shukla⁴, Monika Tanwar⁵, Mona Janak Shah⁶ & Tanvi Hirani⁷

Affiliation

¹Department of Dentistry, Government Medical College, Orai (Jalaun), Uttar Pradesh, India; ²Department of Oral Pathology & Microbiology, Rajarajeswari Dental College & Hospital, Bangalore, India; ³Department of Oral Medicine and Radiology, Maharana Pratap College of Dentistry and Research Centre, Gwalior, Madhya Pradesh, India; ⁴Department of Dentistry, LN Medical College and J K Hospital, Kolar Road, Bhopal, Madhya Pradesh, India; ⁵Department of Oral and Maxillofacial Surgery, SGT University, Gurgaon, Haryana, India; ⁶Department of Oral Medicine & Radiology, Dharmsinh Desai University, Nadiad, Gujarat, India; ⁷Department of Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; *Corresponding author

Email

Akhil Trivedi - E-mail: akt6600@gmail.com; Phone: +91 9457151585
J.K Savita - E-mail: savita29.suresh@gmail.com; Phone: +91 98865 70746
Mayuri Jain - E-mail: dr.mayurijain@gmail.com; Phone: +91 98262 96202
Devashree Shukla - E-mail: shreebalajicbct@gmail.com; Phone: +91 78985 23645
Monika Tanwar Email - E-mail: monikaapril1992@gmail.com; Phone: +91 70270 14582
Mona Janak Shah - E-mail: monashah.fods@ddu.ac.in; Phone: +919427856544
Tanvi Hirani - E-mail: tanvimehta@karnavatiuniversity.edu.in; Phone: +91 96018 00379

Article Type

Research Article

Date

Received March 1, 2026; Revised March 31, 2026; Accepted March 31, 2026, Published March 31, 2026

Abstract

Oral cancer treatment decisions between surgery and non-surgical approaches critically impact survival and quality of life outcomes worldwide. This retrospective cohort study compared surgical treatment (n=98) versus definitive chemoradiotherapy (n=82) in 180 patients with oral squamous cell carcinoma diagnosed 2017-2021. The surgical group demonstrated superior 3-year overall survival (68.4% vs 52.4%, p=0.018) and disease-free survival (61.2% vs 44.0%, p=0.012). Locoregional recurrence was significantly lower with surgery (24.5% vs 39.0%, p=0.032), while distant metastasis rates remained comparable (14.3% vs 17.1%, p=0.608). Surgery provides superior oncologic outcomes for early, localised oral squamous cell carcinoma, while non-surgical options remain valuable for inoperable cases or significant comorbidities.

Keywords

Oral cancer, oral squamous cell carcinoma (OSCC), surgical treatment, chemoradiotherapy, survival outcomes, treatment effectiveness

Citation

Trivedi et al. Bioinformation 22(3): 1374-1381 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.