Title

A clinical study on the comparative effectiveness of micronutrient supplementation and physiotherapy in oral sub-mucous fibrosis

Authors

Nidhi Nidhi^1,*, Sunil Sharma², Uday Narayan Sharma³, M.K. Sunil⁴ & Rohit Sharma¹

Affiliation

¹Department of Oral Medicine & Radiology, NIMS Dental College & Hospital, NIMS University, Jaipur, Rajasthan, India; ²Department of Dentistry, Nims Dental College & Hospital, NIMS University Rajasthan, Jaipur, India; ³Department of TB & Chest, Anughar Narayan Magadh Medical College & Hospital, Bihar, Gaya, India; ⁴Department of Oral Medicine & Radiology, NIMS Dental College & Hospital, NIMS University Rajasthan, Jaipur, India; *Corresponding author

Email

Nidhi Nidhi - E-mail: nidhithakur21@rediffmail.com
Sunil Sharma - E-mail: sunil.sharma@nimsuniversity.org
Uday Narayan Sharma - E-mail: unsharma2859@gmail.com
M.K. Sunil - E-mail: principaldentalcollege@nimsuniversity.org
Rohit Sharma - E-mail: rohitsharmaa@nimsuniversity.org

Article Type

Research Article

Date

Received March 1, 2026; Revised March 31, 2026; Accepted March 31, 2026, Published March 31, 2026

Abstract

Oral Sub-mucous Fibrosis (OSMF) is a chronic, progressive, potentially malignant disorder linked to areca nut chewing. Multiple therapies have been tried, but no consensus exists on the most effective approach. Therefore, it is of interest to compare the effectiveness of micronutrient supplementation and physiotherapy in managing OSMF. Patients with OSMF were randomly assigned to receive either micronutrient supplementation (Group A) or structured physiotherapy (Group B). Outcomes assessed included mouth opening and burning sensation at baseline and follow-up. Both groups showed symptomatic improvement, with physiotherapy yielding significantly greater gains in mouth opening, while both interventions reduced burning sensation. Physiotherapy is more effective than micronutrient supplementation in improving functional outcomes, though both provide symptomatic relief. Combination therapy may be beneficial.

Keywords

Physiotherapy, micronutrient, oral sub-mucous fibrosis

Citation

Nidhi et al. Bioinformation 22(3): 1528-1535 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.