Title

Effect of vitamin D supplementation on fatigue and mood among perimenopausal women

Authors

Prama Ray^1,*, Arshi Srivastava² & Parth Jani³

Affiliation

¹Department of Obstetrics and Gynaecology, Jagannath Gupta Institute of Medical Sciences, North Kolkata Campus, India; ²Department of Biochemistry, Era Medical College, Lucknow, Uttar Pradesh, India; ³Department of General Medicine, Government Medical College, Bhavnagar, Gujarat, India; *Corresponding author

Email

Prama Ray - E-mail: rayprama@gmail.com
Arshi Srivastava - E-mail: sharshi2001@gmail.com
Parth Jani - E-mail: parthjani13@gmail.com

Article Type

Research Article

Date

Received March 1, 2026; Revised March 31, 2026; Accepted March 31, 2026, Published March 31, 2026

Abstract

Perimenopausal women often experience fatigue and mood disturbances, which may be associated with vitamin D deficiency. Therefore, it is of interest to investigate the effect of vitamin D supplementation on fatigue and mood in perimenopausal women with vitamin D deficiency. A randomized, double-blind, placebo-controlled trial included 100 women who received either vitamin D3 or a placebo for 6 months. Results showed significant improvements in both fatigue and mood in the vitamin D group compared to placebo. Multivariate analysis confirmed vitamin D supplementation as a predictor of these improvements. Thus, vitamin D supplementation can effectively alleviate fatigue and improve mood in perimenopausal women with vitamin D deficiency

Keywords

Perimenopause, vitamin D supplementation, fatigue, mood disorders, women’s health

Citation

Ray et al. Bioinformation 22(3): 1638-1642 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.