Title
Blood - brain barrier breakdown and neurovascular unit failure in the progression of Alzheimer's disease
Authors
Suvarna Prasad1,*, Sangeeta Gupta2, Asha Premlata Omega Oraon1,*, Ana Paula Molina Recalde3, Jessica Julieta Cañarte Moreira4, Génesis Nathalie Moyano Salazar3, Paolo David Torres Cañarte3 & Camila Inés Racines Navas3
Affiliation
1Department of Biochemistry, AIIMS, Deoghar, Jharkhand, India; 2Department of Physiology, AIIMS, Gorakhpur, Gorakhpur, Uttar Pradesh, India; 3Department of Medicine, Universidad San Francisco de Quito, Ecuador; 4Department of Medicine, Centro Oncológico del Norte, Antofagasta, Chile; *Corresponding author
Suvarna Prasad - E-mail:
suvarnaprasad999@gmail.com
Sangeeta Gupta - E-mail: drsangeeta77.65@rediffmail.com
Asha Premlata Omega Oraon - E-mail: Ashaoraon84@gmail.com
Ana Paula Molina Recalde - E-mail: anapmolinarecalde@gmail.com
Jessica Julieta Cañarte Moreira - E-mail: jessi.canarte@gmail.com
Génesis Nathalie Moyano Salazar - E-mail:
genesismoyano1839@gmail.com
Paolo David Torres Cañarte - E-mail: paotorrescanarte@gmail.com
Camila Inés Racines Navas - E-mail: camilaracines98@gmail.com
Article Type
Research Article
Date
Received March 1, 2026; Revised March 31, 2026; Accepted March 31, 2026, Published March 31, 2026
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder traditionally defined by amyloid-β deposition and tau pathology. Recent research highlights the role of blood-brain barrier (BBB) breakdown and neurovascular unit (NVU) dysfunction in disease initiation and progression. These factors contribute to neuroinflammation, cerebral hypoperfusion and impaired waste clearance. Despite this, the relationship between BBB integrity, NVU function and cognitive decline in AD remains inadequately understood. Data shows that blood–brain barrier disruption and neurovascular unit dysfunction are critical predictors of cognitive decline in Alzheimer's disease.
Keywords
Blood-brain barrier (BBB), neurovascular unit (NVU), Alzheimer's disease (AD), cognitive impairment, cerebral perfusion
Citation
Prasad et al. Bioinformation 22(3): 1673-1678 (2026)
Edited by
Ritik Kashwani
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
