Title
Effect of premixed and sequential intrathecal fentanyl on spinal block characteristics
Authors
Priyanka Gupta1,*, Utsav Sharma2, Deepak Gupta2, Lokesh Bansal3 & Payal Jain4
Affiliation
1Department of Anesthesiology, S.R.V.S Medical College, Shivpuri, Madhya Pradesh, India; 2Department of Anaesthesiology, DR Laxminarayan Pandey Government Medical College, Ratlam, India; 3Department of Anaesthesiology, Indraprastha Apollo Hospital, New Delhi, India; 4Department of Anaesthesiology, ESIC Medical College & Hospital, Faridabad; *Corresponding author
Priyanka Gupta - E-mail:
drpgupta2005@gmail.com
Utsav Sharma - E-mail: utsavsharma15dec@gmail.com
Deepak Gupta - E-mail: drdeeps29@gmail.com
Lokesh Bansal - E-mail: lokeshbansal664@gmail.com
Payal Jain - E-mail: payalhsr93@gmail.com
Article Type
Research Article
Date
Received March 1, 2026; Revised March 31, 2026; Accepted March 31, 2026, Published March 31, 2026
Abstract
The optimal method of intrathecal fentanyl administration with hyperbaric bupivacaine remains uncertain, as premixed and sequential techniques may influence block characteristics differently. In this prospective observational comparative study, 42 ASA I-II adults (21 per group) received fentanyl 0.5 ml with hyperbaric bupivacaine 2.5 ml either premixed or sequentially. Sequential administration produced faster sensory onset at T10 (5.00±1.37 vs 6.48±1.32 min) and motor onset (6.10±1.37 vs 8.00±1.30 min) with longer sensory and motor regression times. Time to first rescue analgesia was also longer (205.33±12.08 vs 175.38±14.41 min), suggesting earlier onset and prolonged block with the sequential technique.
Keywords
Spinal anaesthesia, subarachnoid block, hyperbaric bupivacaine, Intrathecal fentanyl, premixed technique, Sequential technique
Citation
Gupta et al. Bioinformation 22(3): 1769-1772 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
