Title

Propofol-fentanyl versus propofol-dexmedetomidine: Hemodynamics and recovery during supraumbilical surgery

Authors

Leena Rohilla^1,*, Ritu Sharma² & Rajeev Lochan Tiwari²

Affiliation

¹Department of Anaesthesia, Maharishi Chyawan Medical College, Koriawas Narnaul, Haryana, India; ²Department of Anaesthesia, Fortis Escorts Hospital, Jaipur, Rajasthan, India; *Corresponding author

Email

Leena Rohilla - E-mail: leena.rohilla003@gmail.com; Phone: +91 8168360758

Ritu Sharma - E-mail: jaipurdrhimanshu@yahoo.com; Phone: +91 98291 44467
Rajeev Lochan Tiwari - E-mail: rajeev.tiwari@fortishealthcare.com; Phone: +91 94140 42352

Article Type

Research Article

Date

Received March 1, 2026; Revised March 31, 2026; Accepted March 31, 2026, Published March 31, 2026

Abstract

Propofol requires adjuncts for balanced anaesthesia due to cardiovascular depression and lack of analgesia. Dexmedetomidine offers superior sympatholysis versus opioids like fentanyl but risks delayed recovery. Therefore, it is of interest to compare propofol-fentanyl (PF, n=40) versus propofol-dexmedetomidine (PD, n=40) in 80 ASA I-II adults for elective supra-umbilical surgery. Propofol–dexmedetomidine (PD) better attenuated hemodynamic responses (HR/MAP within 10% baseline) versus 20-25% rises in PF, despite modest recovery delays. PD advances knowledge by optimizing intraoperative stability for supra-umbilical surgery at low early recovery cost.

Keywords

Propofol; fentanyl; dexmedetomidine; hemodynamic stability; recovery profile; general anaesthesia; supra-umbilical surgery

Citation

Rohilla et al. Bioinformation 22(3): 1840-1845 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.