Title
Coexistence of medullary and papillary thyroid carcinoma in the same lobe-isthmus complex: A case report
Authors
Giridhar Murali1,*, Renee Snigdha Arul Anand2, Divyanshu Kumar3, Chandramouli Marimangalam Premchandrababu4, R Sanjay Shankar5 & Anisha Sivakumar5
Affiliation
1Department of Critical Care, Christian Medical College, Vellore, Tamil Nadu, India; 2Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India; 3Department of General Medicine, Medical College, Kolkata, West Bengal, India; 4Department of Head and Neck, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India; 5Department of General Medicine, Madras Medical College, Tamil Nadu, India; *Corresponding author
Giridhar Murali - E-mail: giridharmurali12@gmail.com; Phone: +91 9597130416
Renee Snigdha Arul Anand - E-mail: areneesnigdha07@gmail.com; Phone: +91 9790627795
Divyanshu Kumar - E-mail: doctordk2002@gmail.com; Phone: +91 9829980448
Chandramouli Marimangalam Premchandrababu - E-mail: drchandramoulient@gmail.com; Phone: +91 9940030507
R. Sanjay Shankar - E-mail: rsanjayshankar@gmail.com; Phone: +91 8903227571
Anisha Sivakumar - E-mail: anishaa.sivakumar@gmail.com; Phone: +91 91500 72128
Article Type
Views
Date
Received April 1, 2026; Revised April 30,
2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
The occurrence of coexisting papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) in a single thyroid lobe is considered to be uncommon. A 47-year-old male presented with progressive anterior neck swelling. Upon imaging, the diagnosis of papillary thyroid carcinoma was made and the patient underwent total thyroidectomy and right selective neck dissection. Histopathological examination demonstrated that medullary carcinoma was located within the right lobe and follicular variant PTC was located within the left lobe and isthmus regions. Upon evaluation of the cervical lymph nodes, metastatic medullary carcinoma was noted. Confirmation of the presence of calcitonin in the MTC component and thyroglobulin expression in the PTC component through immunohistochemistry illustrated the importance of using meticulous histopathological and immunohistochemical analysis in making accurate diagnoses and providing individualized treatment options.
Keywords
Medullary thyroid carcinoma (MTC); papillary thyroid carcinoma (PTC); mixed thyroid carcinoma; thyroidectomy
Citation
Murali et al. Bioinformation 22(4): 1959-1964 (2026)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
