Title
Stem cell-based scaffolds using dental pulp and adipose-derived stem cells in periodontal regeneration: Evidence from preclinical or clinical studies
Authors
Manimekalai Muthusamy1,*, Beena George2, Divya Alexander3, Siladitya Sen4, Suma Janya5 & Bindu Devanahalli Rajanna6
Affiliation
1Department of Periodontics, Chettinad Institute of Higher Education and Research, Rajiv Gandhi Salai, Kelambakkam, Chennai, Tamil Nadu, India; 2Department of Oral Pathology and Microbiology, Sree Mookambika Institute of Dental Sciences, Padanilam, Kulasekharam 629161, Tamil Nadu, India; 3Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Cholanagar, Bengaluru, Karnataka, India; 4Department of Dentistry, JIMSH, K. P. Mondal Road, Buita, Budge Budge, Kolkata- 700137, West Bengal, India; 5Department of Prosthodontics, RUAS (Ramaiah university of applied sciences), Msrit Edu campus New BEL Road, Bengaluru - 560064, Karnataka, India; 6Department of Periodontology, Dayanada Sagar College of Dental Sciences, Kumaraswamy Layout, Bengaluru, Karnataka 560111, India;
*Corresponding author
Manimekalai Muthusamy - E-mail: drmanimekalaiperio@gmail.com; Phone: +91 9944686569
Beena George - E-mail: beenimm6@gmail.com; Phone: +91 9446440781
Divya Alexander - E-mail: divyaalexander849@gmail.com
Siladitya Sen - E-mail: dr.sen02@yahoo.com; Phone: +91 9741870734
Suma Janya - E-mail: sumajanya007@gmail.com; Phone: +91 9739004015
Bindu Devanahalli Rajanna - E-mail: bindhudr123@gamil.com; Phone: +91 89044 79704
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Current periodontal therapies fail to predictably restore the complete architecture of alveolar bone, periodontal ligament and cementum lost due to periodontal disease. Stem cell–based scaffolds have emerged as a biological strategy to enhance coordinated periodontal regeneration through combined cellular and biomaterial approaches. Therefore, it is of interest to evaluate preclinical and clinical evidence on dental pulp stem cell and adipose-derived stem cell–based scaffolds in periodontal regeneration. Animal studies consistently demonstrate enhanced new bone formation, cementum-like tissue deposition, organized periodontal ligament–like fibers and improved vascularization compared to scaffold-only controls. Thus, we report reductions in probing depth, gains in clinical attachment and favorable safety profiles, although standardized protocols and long-term data remain limited.
Keywords
Periodontal regeneration; stem cell–based scaffolds; dental pulp stem cells (DPSC); adipose-derived stem cells; tissue engineering; periodontal tissue engineering; alveolar bone regeneration; preclinical models; clinical applications
Citation
Muthusamy et al. Bioinformation 22(4): 2015-2019 (2026)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
