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Title

The effects of zinc oxide eugenol, calcium hydroxide, bioactive glass, resin and bioceramic canal sealers on post-operative pain: A randomized clinical trial

 

Authors

Shriya Mitna*, Santosh Kumar Singh, Yashwani Jain, Kapil Malviya & Sakshi Agrawal

 

Affiliation

Department of Conservative Dentistry and Endodontics, People's College of Dental Sciences and Research Centre, People's University, Bhopal, Madhya Pradesh, India; *Corresponding author

 

Email

Shriya Mitna - E-mail: shriya.mitna21@gmail.com

Santosh Kumar Singh - E-mail: santoshsingh37@gmail.com

Yashwani Jain - E-mail: yashwanijain225@gmail.com

Kapil Malviya - E-mail: iamkapil17@gmail.com

Sakshi Agrawal - E-mail: sakshiagrawal299@gmail.com

 

Article Type

Research Article

 

Date

Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026

 

Abstract

Post-operative pain after root canal treatment is still a common clinical issue that can make patients less comfortable and less likely to accept endodontic therapy. Therefore, it is of interest to assess post-operative pain associated with five distinct root canal sealers bioactive glass-based, bioceramic-based, calcium hydroxide–based, resin-based and zinc oxide eugenol-based-using single-rooted premolars exhibiting symptomatic apical periodontitis. Hence, a total of 135 patients were randomly assigned to five groups (n = 27) and pain was measured using the visual analog scale at different time points after surgery. Bioactive glass-based sealers had the lowest pain scores after surgery, while zinc oxide eugenol-based sealers had higher pain levels in the first few days after surgery. Over time, pain levels decreased slowly across all groups. Thus, bioactive sealers may help reduce pain immediately after root canal treatment.

 

Keywords

Bioactive glass sealer; post-operative pain; root canal treatment; endodontic sealers; visual analog scale (VAS)

 

Citation

Mitna et al. Bioinformation 22(4): 2079-2082 (2026)

 

Edited by

Vini Mehta

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.