Title

Estimation of gut microbiome motif associated with active tuberculosis - A case control study

Authors

Meenal Jain¹, Tanya Jain², Rajat Nayak^3,*, Talha Saad⁴, Akash Wamanrao Karale^5, Mohammad Ilyas⁶ & Ravikant Arjariya⁷

Affiliation

¹Department of Anaesthesiology, Bundelkhand Government Medical College Sagar, Madhya Pradesh, India; ²Department of Anaesthesiology, R.D. Gardi Medical College, Ujjain, Madhya Pradesh, India; ³Department of Emergency Medicine, Bundelkhand Government Medical College Sagar, Madhya Pradesh, India; ⁴Department of Respiratory Medicine, Bundelkhand Medical College Sagar, Madhya Pradesh, India; ⁵Department of surgery, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ⁶Department of Anaesthesia, Bundelkhand medical College Sagar, Madhya Pradesh, India; ⁷Department of Physiology, Bundelkhand Government Medical College, Sagar, Madhya Pradesh, India; *Corresponding author

Email

Meenal Jain - E-mail: meenaljain4444@gmail.com

Tanya Jain - E-mail: tanyajain278@gmail.com

Rajat Nayak - E-mail: dr_rajatnayak1515@yahoo.com

Talha Saad - E-mail: dr.talhasaad@gmail.com

Akash Wamanrao Karale - E-mail: akashkarle1.ak@gmail.com

Mohammad Ilyas - E-mail: dr.ilyas786@gmail.com

Ravikant Arjariya - E-mail: arjariyaravikant@gmail.com

Article Type

Research Article

Date

Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
 

Abstract

Tuberculosis (TB) is the most tenacious health issue affecting individuals globally. Therefore, it is of interest to estimate gut microbiota motifs associated with the outbreak of active TB by incorporating the insights from human case-control data. 106 respondents were categorised into 2 groups: group A with TB and group B controls with 53 respondents in each category. The Shannon diversity index was substantially diminished in affected individuals. The active TB cases exhibited substantially decreased microbiomes (P < 0.001). Thus, we show the need to develop microbiome-targeted strategies to reduce the incidence of active TB cases and improve their effective management.

Keywords

Tuberculosis (TB), gut microbiota, gut–lung axis, dysbiosis

Citation

Jain et al. Bioinformation 22(4): 2083-2086 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.