Title

Linking clinical presentation and histopathological data in perforation peritonitis

Authors

Kusum Mahour¹, Pradeep Rathore¹ & Aasha Baghel^2,*

Affiliation

¹Department of General Surgery, Government Medical College, Datia, Madhya Pradesh, India; ²Department of Pathology, Government Medical College, Datia, Madhya Pradesh, India; *Corresponding author

Email

Kusum Mahour - E-mail: kusummahour5@gmail.com; Phone: +91 9039795161

Pradeep Rathore - E-mail: prathore663@gmail.com; Phone: +91 8463044344

Aasha Baghel - E-mail: draashabaghel@gmail.com; Phone: +91 7780832669

Article Type

Research Article

Date

Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
 

Abstract

Perforated peritonitis presents a diagnostic challenge because clinical manifestations often poorly correlate with the underlying histopathological severity and etiology. This prospective observational study included 50 patients with perforated peritonitis who underwent emergency laparotomy, assessing clinical parameters such as presenting symptoms, duration of illness, pain location, hemodynamic status and laboratory findings. Intraoperative details including the site and size of perforation, degree of peritoneal contamination and associated pathology were recorded and histopathological examination was performed on resected specimens and biopsy samples from perforation margins. Statistical analysis revealed a strong association between clinical presentation and histopathological severity, confirming that clinical features can reflect the underlying pathological burden. Thus, histopathological analysis is indispensable for accurate etiological diagnosis and for guiding postoperative management in perforated peritonitis.

Keywords

Perforation peritonitis, histopathology, clinical correlation, laparotomy, gastrointestinal perforation

Citation

Mahour et al. Bioinformation 22(4): 2097-2101 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.