Title
Low T3 syndrome and short-term outcomes in patients with acute decompensated heart failure: A retrospective observational study
Authors
Noorussaba Arfeen*, Devendra Kumar Sinha & Kaushal Kishore
Affiliation
Department of General Medicine, Patna Medical College and Hospital (PMCH), Patna, Bihar, India; *Corresponding author
Noorussaba Arfeen - E-mail: arfeennoor@gmail.com; Phone: +91 8084509293
Devendra Kumar Sinha - E-mail: devkrsinha48@gmail.com; Phone: +91 8294029777
Kaushal Kishore - E-mail: kaushalkishore327@gmail.com; Phone: +91 9835405667
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Acute decompensated heart failure (ADHF) drives frequent hospitalizations with high short-term morbidity/mortality, yet low triiodothyronine (T3) syndrome characterized by unexplained low serum free T3 remains understudied as a prognostic marker in resource-limited ADHF settings. Therefore, it is of interest to assess the prevalence of low T3 and its association with in-hospital mortality, length of stay and 30-day readmission in 115 ADHF patients. Low T3 syndrome affected 40.9% (47/115) of patients, who exhibited higher in-hospital mortality (25.5% versus 7.4%, p=0.006), longer stays (9.8±3.6 versus 6.9±2.4 days) and greater 30-day readmissions (34.3% versus 15.9%) than normal T3 controls. Multivariate analysis confirmed that low T3 was an independent predictor of mortality (adjusted OR 3.42, 95% CI 1.28–9.15, p=0.014) after adjusting for age, ejection fraction and creatinine. Thus, we show low T3 syndrome as a prevalent, actionable prognostic biomarker for risk stratification and targeted intervention in resource constrained ADHF management.
Keywords
Low triiodothyronine (T3) syndrome, acute decompensated heart failure (ADHF), short-term outcomes, in-hospital mortality, euthyroid sick syndrome
Citation
Arfeen et al. Bioinformation 22(4): 2112-2117 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
