Title
Comparative evaluation of topical and intramuscular coenzyme Q10 application in non-surgical periodontal disease management: A randomized clinical study
Authors
Shalini Sinha1, Kausar Parwez Khan1,*, Rupam Kumari Rupam1, Ria Jha1, Akshta Singh1 & K. Mohamed Adhil2
Affiliation
1Department of Periodontology and Implantology, Mithila Minority Dental College and Hospital, Darbhanga, Bihar, India; 2Department of Periodontology, Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, Tamil Nadu, India; *Corresponding author
Shalini Sinha - E-mail: shalinissinha9@gmail.com; Phone: +91 7709019535
Kausar Parwez Khan - E-mail: kausar5983@gmail.com; Phone: +91 6207177745
Rupam Kumari Rupam - E-mail: krupam3005@gmail.com; Phone: +91 8340500787
Ria Jha - E-mail: riajhaofficial@gmail.com; Phone: +91 9654507333
Akshta Singh - E-mail: akshta16nov@gmail.com; Phone: +91 9958052854
K. Mohamed Adhil - E-mail: chat2adhilk@gmail.com
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Periodontal disease remains challenging to manage because adjunctive antioxidant therapies are not well-standardized forroute of administration or dosing relative to scaling and root planing (SRP). Therefore, it is of interest to evaluate SRP alone, SRP plus topical CoQ10 and SRP plus intrasulcular CoQ10 at 150 sites in 50 patients with chronic periodontitis over 4 weeks. Plaque Index, Gingival Index, Modified Sulcular Bleeding Index and Probing Pocket Depth were assessed at baseline and follow-up in all three groups. All groups showed significant improvement, but Group 3 (intrasulcular CoQ10 + SRP) demonstrated the greatest reduction in probing pocket depth, from 6.52±1.07 mm to 3.67±0.28 mm (p = 0.000). Thus, intrasulcular CoQ10 + SRP is superior for periodontal regeneration opening new adjunctive antioxidant therapy pathways.
Keywords
Coenzyme Q10; chronic periodontitis; scaling and root planing (SRP); intrasulcular drug delivery; topical application; periodontal therapy; antioxidants; probing pocket depth (PPD)
Citation
Sinha et al. Bioinformation 22(4): 2174-2178 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
