Title
Short-term effectiveness of three agents for dentin hypersensitivity treatment: A randomized clinical trial
Authors
Ankita Garg1,*, Mohit Garg2 & Mohan Rawat2
Affiliation
1Department of Dentistry, Shyam Shah Medical College, Rewa, Madhya Pradesh, India; 2Department of Periodontology, K.D. Dental College and Hospital, Mathura, Uttar Pradesh, India; *Corresponding author
Ankita Garg - E-mail: anky14.ag@gmail.com; Phone: +91 7017930270
Mohit Garg - E-mail: mohit.garg99@gmail.com; Phone: +91 9319682118
Mohan Rawat - E-mail: mohanrawat011@gmail.com; Phone: +91 8791541676
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Dentin hypersensitivity is common and many desensitizing agents exist, but comparative data across products and delivery methods remain limited. Therefore, it is of interest to compare three interventions-GLUMA Desensitizer, Clinpro XT Fluoride Varnish and 1.23% APF gel with iontophoresis applied in 75 patients using two stimuli (cold air blast and explorer scratching) and assessed by VAS at six time points up to 120 days. All three groups showed significant reductions in hypersensitivity over time on both stimuli, with the greatest VAS decline seen in the APF–iontophoresis group, particularly under air blast stimulation (mean change 63.28±12.80; p<0.001). No significant intergroup differences were observed with explorer scratching, suggesting stimulus dependent discrimination of efficacy. Thus, we show that 1.23% APF gel with iontophoresis provides the most sustained and clinically meaningful relief, supporting its preferential use for long-term management of air-induced dentin hypersensitivity.
Keywords
Dentin hypersensitivity (DH), acidulated phosphate fluoride (APF) gel, iontophoresis, GLUMA, Clinpro XT, visual analog scale (VAS) score
Citation
Garg et al. Bioinformation 22(4): 2206-2212 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
