Title
Comparative evaluation of nano-hydroxyapatite dentifrice, diode laser alone and combined for dentin hypersensitivity: A randomized clinical trial
Authors
Ekata Jaindesarda1, Lisa Chacko2, Ruhi Subhash Sankpal3, Farhan Abdul Azeez4,*, Sanyukta Singh5 & Maithili Madhukar Kshirsagar6
Affiliation
1Private Practitioner, Periodontists, Ace dental care, Pune, India; 2Department of Periodontics, SMBT Dental College & Hospital, Sangamner, Maharashtra, India; 3Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Sangli, Maharashtra; 4Registrar Endodontics, Al Hammadi Hospital, Prince Muqrin Ibn Abdulaziz St, An Nuzhah, Riyadh, Kingdom of Saudi Arabia; 5Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, SIMATS, Chennai, Tamil Nadu, India; 6Department of Oral Medicine & Radiologist, Nanded Rural Dental College and Research Center, Nanded, India; *Corresponding author
Ekata Jaindesarda - E-mail: ekatajain75@gmail.com; Phone: +91 8805557907
Lisa Chacko - E-mail: lisabrahamj@gmail.com; Phone: +91 7378488875
Ruhi Subhash Sankpal - E-mail: ruhi.sankpal@bharatividyapeeth.edu; Phone: +91 8830146895
Farhan Abdul Azeez - E-mail: drfarhanendo@gmail.com; Phone: +96 6550907798
Sanyukta Singh - E-mail: singhsanyukta95@gmail.com; Phone: +91 8178317800
Maithili Madhukar Kshirsagar - E-mail: maithilikshirsagar21@gmail.com; Phone: +91 8485801962
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Dentin hypersensitivity is a common clinical condition characterized by short, sharp pain arising from exposed dentinal tubules, posing a challenge for long-term management. This randomized, single-blind parallel-arm clinical trial evaluated and compared the effectiveness of nano-hydroxyapatite (N-HAP) dentifrice and diode laser used alone and in combination, with fluoride dentifrice as a control. Fifty-five hypersensitive sites were allocated into four groups and sensitivity was assessed using VAS and VDS scores at baseline, immediately post-treatment and at 1, 4 and 8 weeks. All test groups demonstrated a significant reduction in dentin hypersensitivity compared to the control group, with the combination therapy showing the greatest and most sustained reduction. The combined use of N-HAP dentifrice and diode laser exhibits a superior synergistic effect, indicating its potential as an effective approach for managing dentin hypersensitivity.
Keywords
Dentin hypersensitivity (DH); desensitizing agents; diode laser; nano-hydroxyapatite (N-HAP)
Citation
Jaindesarda et al. Bioinformation 22(4): 2380-2387 (2026)
Edited by
Neelam Goyal & Shruti Dabi
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
