Title
Comparison of salivary caspase-3 biomarker in peri implantitis
among type 2 diabetic patients
Authors
Madhu Kiran1, Awadesh Kumar Gupta2,*, Deepak Bala3, Gopinath Parakkat Vynat4, K. Rajesh Kumar5, S.M Manjunath6, Syed Fareed Mohsin7 & Bassam Mohammed Almutairi8
Affiliation
1Department of Conservative Dentistry and Endodontics, Sri Venkateswara Dental College, Bannerghatta, Bengaluru, Karnataka, India; 2Department of Oral Pathology and Microbiology, DJ College of Dental Sciences and Research, Modinagar, Ghaziabad, Uttar Pradesh, India; 3Department of Periodontology, Rayat Bahra Dental College and Hospital, Mohali, Punjab, India; 4Department of Periodontology and Implantology, Sree Anjaneya Institute of Dental Sciences, Kozhikode, Kerala, India; 5Department of Prosthodontics, Malabar Dental College, Kerala, India; 6Department of Oral and Maxillofacial Pathology, Dental College & Hospital, College of Dental Sciences, Jammu, India; 7Department of Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, Qassim University, Buraydah, Sauid Arabia; 8Department of Oral and Maxillofacial Surgery, College of Dentistry, Qassim Univesrity, Buraydah 52571, Saudi Arabia; *Corresponding author
Madhu Kiran - E-mail: endocmk@gmail.com
Awadesh Kumar Gupta - E-mail: drawadeshgupta@gmail.com
Deepak Bala - E-mail: drdeepakbala@gmail.com
Gopinath Parakkat Vynat - E-mail: drgopi41@yahoo.com
K. Rajesh Kumar - E-mail: Drrkkunnath@gmail.com
S.M Manjunath - E-mail: drmanjunathsirsalmath@gmail.com
Syed Fareed Mohsin - E-mail: s.syedabdulmohsin@qu.edu
Bassam Mohammed Almutairi - E-mail: bassam.alhumaiani@gmail.com
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Diagnostic biomarker-based methodologies have become the form of reliable non-invasive measures of diagnosis of peri-implant disorders at the earliest possible stage. Therefore, it is of interest to determine efficacy of salivary caspase-3 levels as a non-invasive biomarker of early peri-implantitis (PI) diagnosis in diabetic patients with type 2 diabetes. The number of participants was 36, which was separated into three groups. Group I- PI with the presence of the diabetes mellitus (DM + PI) and group II- PI without the diabetes mellitus (NDM + PI) and group III- periodontally healthy and no diabetes mellitus (NDM + PH). Each of the participants had unstimulated whole saliva (10 mL) collected. Centrifugation and Salivary caspase-3 levels quantification was done on samples by using a commercially available Human Caspase-3 enzyme-linked immunosorbent assay kit. The data obtained was statistically tested. Caspase-3 has the potential of being a non-invasive salivary biomarker in high-risk groups.
Keywords
Caspase-3, diabetes mellitus, enzyme-linked immunosorbent assay, peri-implantitis
Citation
Kiran et al. Bioinformation 22(4): 2405-2408 (2026)
Edited by
P Babaji
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
