Title

A prospective randomized study comparing amoxycillin/clavulanate (augmentin) with cefuroxime-metronidazole as prophylaxis in gynaecological surgery

Authors

Shambhavi Soni¹, Pradeep Rathore² & Ashis Tiwari^3,*

Affiliation

¹Department of Obstetrics and Gynaecology, Government Medical College, Datia, Madhya Pradesh, India; ²Department of General Surgery, Government Medical College, Datia, Madhya Pradesh, India; ³Department of General Medicine, Government Medical College, Datia, Madhya Pradesh, India; *Corresponding author

Email

Shambhavi Soni - E-mail: drshambhavisoni@gmail.com; Phone: +91 9088088252

Pradeep Rathore - E-mail: Prathore663@gmail.com; Phone: +91 8463044344

Ashis Tiwari - E-mail: ashishtiwari.gwldr@gmail.com; Phone: +91 6263218871

Article Type

Research Article

Date

Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026

Abstract

Effective antibiotic prophylaxis is essential for preventing post-operative infections following gynecological surgery. This prospective randomized study conducted in a tertiary care hospital compared the efficacy of amoxicillin–clavulanate and cefuroxime metronidazole as preoperative antibiotic regimens. Hence, two hundred women undergoing elective gynecological procedures were evenly divided into two groups: GroupA received 1.2g amoxicillin–clavulanate intravenously, while GroupB received 1.5g cefuroxime plus 500mg metronidazole before surgical incision. Post-operative outcomes such as surgical site infection, febrile morbidity, urinary tract infections and duration of hospital stay were recorded and analyzed using SPSS, with significance set at p < 0.05.  Thus, we show that both antibiotic combinations were equally effective in reducing post-operative infection rates and were well tolerated, supporting their safe use in gynecological surgery and the choice between regimens may depend on factors including hospital antibiotic policy, cost and local microbial resistance patterns.

Keywords

Gynecological surgery, antibiotic prophylaxis, amoxycillin–clavulanate, cefuroxime, metronidazole, surgical site infection (SSI)

Citation

Soni et al. Bioinformation 22(4): 2578-2582 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.