Title
Comparative evaluation of antimicrobial efficacy for different root canal irrigants against Enterococcus faecalis - An in vitro study
Authors
Shah Maruf Hussain1,*, Shipra Jaidka1, Deepti Jawa1, Alisha Hoda2 & Shailesh Kumar1
Affiliation
1Department Pediatric and Preventive Dentistry, Divya Jyoti College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India; 2Department of Dental surgery, AM Dental Care, Kalkaji, New Delhi, India; *Corresponding author
Shah Maruf Hussain - E-mail: niclosmaruf@gmail.com; Phone: +91 8240893829
Shipra Jaidka - E-mail: shiprajaidka2@gmail.com; Phone: +91 9412522914
Deepti Jawa - E-mail: jawadewpti@rediffmail.com; Phone: +91 9720038877
Alisha Hoda - E-mail: alishroses@gmail.com; Phone: +91 8076749744
Shailesh Kumar - E-mail: shailesh.singh947@gmail.com; Phone: +91 9415001470
Tanushree Basu - E-mail: ms.tanushreebasu@gmail.com; Phone: +91 9721510135
Article Type
Research Article
Date
Received April 1, 2026; Revised April 30, 2026; Accepted April 30, 2026, Published April 30, 2026
Abstract
Persistent endodontic infections often involve resistant Enterococcus faecalis, making effective root canal irrigation essential for microbial control and treatment success. Therefore, it is of interest to assess antimicrobial efficacy against E. faecalis (MTCC 9845) using silver nanoparticles, BioPure MTAD and sodium hypochlorite across 40 Mueller-Hinton agar wells. Sodium hypochlorite demonstrated maximum zone of inhibition, followed closely by BioPure MTAD, while silver nanoparticles showed moderate activity; distilled water served as a negative control with no inhibition. NaOCl remains the gold-standard irrigant due to its superior antimicrobial activity against persistent endodontic pathogens. Thus, BioPure MTAD as a safer, near-equivalent alternative, guiding safer irrigation protocols for resistant infections.
Keywords
Endodontic irrigants; sodium hypochlorite; BioPure MTAD; silver nanoparticles; Enterococcus faecalis
Citation
Hussain et al. Bioinformation 22(4): 2583-2587 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
