Title

Polymerized injectable platelet-rich fibrin with octacalcium phosphate (bontree®) for treatment of periodontal intrabony defects assessed using CBCT: A randomized controlled clinical trial

Authors

P.P Safwana*, Sreekanth Puthalath, Deepak Thomas, Deepu Mathews Panickal, N Shahna & Maria Thomas

Affiliation

Department of Periodontics and Implantology, Educare Institute of Dental Sciences, Malappuram, Kerala, India; *Corresponding author

Email

P.P Safwana - E-mail: safwanapp95@gmail.com
Sreekanth Puthalath - E-mail: srk.puthalath@gmail.com
Deepak Thomas - E-mail: drthomasdeepak@gmail.com
Deepu Mathews Panickal - E-mail: drdeepumathewmds@gmail.com
N. Shahna - E-mail: Shahna.tgi@gmail.com
Maria Thomas - E-mail: mariathekkedathu@gmail.com

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Periodontal intrabony defects remain a significant clinical challenge due to the difficulty in achieving predictable regeneration of lost alveolar bone. Therefore, it is of interest to evaluate the effectiveness of injectable platelet-rich fibrin (I-PRF) polymerized with octacalcium phosphate (OCP) compared to OCP alone in treating intrabony defects using a split-mouth design. Hence, twelve patients with chronic periodontitis contributed twenty-four sites, assessed clinically and radiographically using CBCT at baseline and six months. Both groups demonstrated significant improvements in clinical and radiographic parameters, with greater percentage changes observed in the I-PRF + OCP group, although intergroup differences were not statistically significant. The adjunctive use of polymerized I-PRF with OCP shows a favorable trend in enhancing periodontal regeneration and warrants further investigation in larger studies.

Keywords

Injectable platelet-rich fibrin, octacalcium phosphate (OCP), cone-beam computed tomography (CBCT), periodontal regeneration

Citation

Safwana et al. Bioinformation 22(5): 2718-2723 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.