Title

Comparative evaluation of platelet-rich fibrin and collagen membrane for guided bone regeneration in alveolar defects

Authors

Nitish Kumar Kompalli^1,*, Shivani Mishra², Tamma Prathyusha Reddy³, Isha Agrawal⁴, Rajat Dabholkar⁵ & Sukanya Mishra⁶

Affiliation

¹Department of Dentistry, Kotilingam's Dental Clinic, Guntur Andhra Pradesh, India; ²Department of Dentistry, Virendra Kumar Sakhlecha Government Medical College, Neemuch, Madhya Pradesh, India; ³Department of Dentistry, Sri Ramachandra institute of higher education and research, Chennai, Tamil Nadu, India; ⁴Department of Periodontics and Implantology, Manubhai Patel Dental College and Hospital, Vadodara, Gujarat, India; ⁵Department of Prosthodontics and Crown & Bridge, Yogita Dental College and Hospital, Khed, Maharashtra, India; ⁶Department of Periodontics, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India; *Corresponding author

Email

Nitish Kumar Kompalli - E-mail: nitishkompalli@outlook.com
Shivani Mishra - E-mail: shivani24mishra@gmail.com
Tamma Prathyusha Reddy - E-mail: prathyusha.reddy0709@gmail.com
Isha Agrawal - E-mail: ishadent@yahoo.com
Rajat Dabholkar - E-mail: Drrajaatd94@gmail.com
Sukanya Mishra - E-mail: drmishrasukanya@gmail.com

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Alveolar bone defects following tooth loss, trauma, or pathology compromise implant placement and prosthetic rehabilitation, necessitating effective guided bone regeneration strategies. Therefore, it is of interest to compare the clinical and radiographic outcomes of platelet-rich fibrin (PRF) and resorbable collagen membranes in alveolar defect regeneration. Hence, forty patients were randomly allocated into PRF (n=20) and collagen membrane (n=20) groups, both combined with particulate bone graft, with evaluation of healing parameters and CBCT-based bone gain at baseline and 6 months. Both groups demonstrated significant bone regeneration, with slightly greater horizontal gain in the collagen group, while vertical gain and complication rates showed no statistically significant differences. PRF and collagen membranes exhibit comparable regenerative efficacy, with PRF offering additional advantages of autologous origin, cost-effectiveness, and enhanced soft tissue healing.

Keywords

Platelet-rich fibrin (PRF), collagen membrane, guided bone regeneration, alveolar defect, bone augmentation

Citation

Kompalli et al. Bioinformation 22(5): 2779-2785 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.